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hypertrichosis ( Werewolf syndrome - Ambras syndrome )

is an abnormal amount of hair growth on the body

Kholoud Elwan

on 23 February 2015

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Transcript of hypertrichosis ( Werewolf syndrome - Ambras syndrome )

(werewolf syndrome )

which occur over
the entire body
which is restricted
to a certain area
Before birth
after birth
extremely rare
always present at birth
multiple causes
appears after birth
be reduced with various treatments
Signs and symptoms
excessive hair
androgen excess disorder.
In most cases, hypertrichosis is genetic
drugs and toxins (like mercury)
malnutrition or an untreated infection
Done by : Kholoud AL Mahdy
Repeated shaving
bleaching of the hair
permanent electrolysis
Chemical epilation
laser hair removal
Thank you for
listening ....


is an abnormal amount of hair growth on the body

first identified: in 1982 by
an American geneticist called
Frank Greenberg
History Behind syndrome
To review the causes, presentation, and therapy of primary generalized and localized symmetrical hypertrichosis in children.
Case series of 11 prepubertal male and female patients who had idiopathic hypertrichosis between July 1, 1990, and November 30, 1999.
Case 1

*Was born with long, coarse, dark brown hair on her forehead, back,abdomen,arms and legs

*maternal great-uncle reported with generalized hypertrichosis.

* The complete blood cell count, hormone level, follicular-stimulating hormone level, free testosterone level, total testoster ane level, and sex hormone–binding globulin level were normal.

*Chromosome analysis showed a 46,XX genotype.

*Gingival hypertrophy with dystrophic teeth.

Dr . Ali ElKebalawy
Dr. Kareem Mosa
1-University of Sharjah - Department Of biotechnology
2- Sharjah University Hospital
Dr. Fatma Mostafa / Dermatologist

Fatma Mohamed Mostafa Shaban
Dermatologist & Laser Specialist

Consultant Dermatologist - Umm Al Quwain Hospital,

Consultant dermatologist in Sharjah - University Hospital, Sharjah, UAE
" Hyperetrichosis cases are about 10 to 12 cases per month come to me are suffering from different taype of Hypertrichosis" ( Fatma M. )
** Also by searching on the Helth minstry site, there were no any records for hypertrichosis !
Social Communication
1 . http://archderm.jamanetwork.com/article.aspx?articleid=478429

2. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113246/


Mariam Karaman
Yara Karaman
Fatma Al Khodary
Nesreen Al Khofash
3 - My Colleagues :
Generalized Hypertrichosis
X Chromosome region q27.1
*A 6-year-old girl

long hair growth 50%

matted rough hair
*anagora (go ) gene
Genetic mutation
Anagen: follicular regeneration

Catagen: cell proliferation ceases and the hair follicle shortens;

Telogen, the stage during which the hair is shed.
Hair Growth stages :
Under supervision of :
Dr. Ali El Kabalawy
Dr. Kareem Mosa
Primary hypertrichotic conditions, whether localized or generalized, are rare in pediatric patients n. Although otherwise benign, these disorders may result in cosmetic disfigurement and psychosocial trauma for patients and families. Patients and their families should be adequately advised of the available treatment methods for both temporary and permanent hair removal
Eleven patients with primary generalized or symmetrical localized hypertrichosis were identified;

all had medical records and photographs available for review. , the following data were collected: sex, age, race, medical history, drug history, distribution of increased hair growth, patient's age of onset of excess hair growth, change in pattern of hair growth, family history of increased hair growth, and treatments attempted.
Material And Method
Full transcript