Loading presentation...
Prezi is an interactive zooming presentation

Present Remotely

Send the link below via email or IM

Copy

Present to your audience

Start remote presentation

  • Invited audience members will follow you as you navigate and present
  • People invited to a presentation do not need a Prezi account
  • This link expires 10 minutes after you close the presentation
  • A maximum of 30 users can follow your presentation
  • Learn more about this feature in our knowledge base article

Do you really want to delete this prezi?

Neither you, nor the coeditors you shared it with will be able to recover it again.

DeleteCancel

Make your likes visible on Facebook?

Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.

No, thanks

Anatomy & Physiology: HPA Axis

No description
by

james donahue

on 21 April 2017

Comments (0)

Please log in to add your comment.

Report abuse

Transcript of Anatomy & Physiology: HPA Axis

XX fetuses can be markedly virilized with ambiguous genitalia
both genders may present precocious puberty
glycyrrhizinic acid (inhibits 11 - hydroxylase)
CRH
+
The Hypothalamic-Pituitary-
Adrenal Axis (HPA)

Goals:
Review the structure of the pituitary
Contrast the anterior and posterior lobes
Diagram the feedback control of hormone release
Describe the action of ACTH
Identify the functional zones of the adrenal gland
List the major actions of adrenal cortical hormones
Describe the actions of glucocorticoid hormones in stress
Explain the control of glucocorticoid secretion
Diagram the biosynthetic pathway of the adrenal cortical hormones
Predict the effects of interrupting the biosynthetic pathway on glucocorticoid and mineralcorticoid production and activity

Anterior
Pituitary
Posterior
Pituitary
Hypothalamus
GHIH
GHRH
TRH
PIH
GnRH
CRH
OT
ADH
uterine contractions,
milk let-down
vasoconstriction,
water conservation
January 2013
Hypothalamic neurons
synthesize OT and ADH
OT and ADH are transported down the hypothalamic-hypophyseal tract to the posterior pituitary
OT and ADH are released from the axon terminals into the blood stream
Posterior
Pituitary
Hypothalamic neurons
synthesize and secrete releasing or inhibiting hormones into the capillaries of the hypophyseal portal system
Hypothalamus
Hypothalamus
Hypothalamic
Hormones
GHRH, GHIH, TRH, PIH, GnRH, CRH
Hypothalamic hormones travel through portal vessels to stimulate or inhibit anterior pituitary hormones
Anterior pituitary
secretes hormones
into circulation
Anterior Pituitary
Hormones
GH, TSH, FSH,
LH, PRL, ACTH
Anterior
Pituitary
Anterior
Pituitary
Posterior
Pituitary
AKA
Adenohypophysis
AKA

Neurohypophysis
Pituitary gland
Hypothalamus
Embryologic development
of the pituitary gland

Nmemonic for the pituitary hormones
TOGA FLAP
Feedback Control of Hormone Release
Hypothalamus
Anterior Pituitary
Adrenal Cortex
ACTH
Cortisol
ACTH
+
-
-
GH
TSH
ACTH
FSH
LH
PRL
somatomedin release
T3 and T4 release
The Adrenal Cortex
Glomerulosa
Fasciculata
Reticularis
Medulla
Capsule
Mineralocorticoids
Aldosterone
Glucocorticoids
Cortisol
Gonadocorticoids
Sex Hormones
Catecholamines
Epinephrine and
Norepinephrine
stimulate milk production
testosterone release
estrogen and progesterone release
follicular maturation
spermatogenesis
cortisol release
The Biosynthetic Pathway of the Adrenal Cortex Hormones
11 -hydroxylase deficiency
17 -hydroxylase deficiency
21-hydroxylase deficiency
Congenital Adrenal
Hyperplasia
autosomal recessive diseases resulting from mutations of genes for enzymes mediating steriodogenesis
decreased cortisol
increased ACTH
increased androgens
increased corticosterone
(weak corticosteroid)
increased ACTH
increased aldosterone
decreased androgens
decreased aldosterone
increased androgens
increased sodium retention
hypertension
undervirilization in XY fetuses (hypogonadism)
appears equally in both genders, but if not checked by karyotype, most appear female
most common CAH
"salt wasting"
XX fetuses may be mildly to severely virilized
What if a pituitary tumor caused a hypersecretion of ACTH?
Function of Cortisol?
Stress hormone
Increase blood sugar
Increase sugar, fat, and protein metabolism
Suppress the immune system (anti-inflammatory)
Cushing's Disease
Purple/red striae due
to stretching skin
Growth of fat pads
in the cervical area
Hirsuitism
Rapid weight gain
What if there are limited
receptors for ACTH?
Decerased cortisol - fatigue
Decreased aldosterone - hypotension
Increased MSH
- hyperpigmentation
Addison's Disease
http://lat.ms/L3wuhY
http://bit.ly/10PQ21S
Amy Cuddy: Your body language shapes who you are
Axis - a linear controlled structure comprised by a series of cells secreting hormones to stimulate subsequent cells
Great Attire And

Fast Cars Are

Really Sexy Attributes
G
ranulosa -
A
ldosterone after
A
ngiotensin II

F
asciculata -
C
ortisol after
A
CTH

R
eticularis -
S
ex Hormones after
A
CTH
Nmemonic for the Hormones
of the Adrenal Cortex
Please download the free QR reader for your mobile device
Full transcript