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Maurice Wilkins and Rosalind Franklin
Transcript of Maurice Wilkins and Rosalind Franklin
If I were an enzyme I would be DNA helicase so I could unzip your genes. By: Cathleen Bui
Khoi Pham Experiment BRIEF BIOGRAPHY Rosalind Franklin (1920-1958) Born in Nottinghill, London
Attended Cambridge University (Ph.D)
as a British biophysicist and X-ray crystallographer
best known for her work on the x-ray diffraction images of DNA which led to the discovery of DNA double helix
Death due to ovarian Cancer
Franklin did not receive honorable recognition for her contributions.
BRIEF BIOGRAPHY Maurice Wilkins (1916-2004) Born in New Zealand
physicist and molecular biologist
best known for his work on the structure of DNA.
Contributed to the scientific understanding of phosphorescence, isotope separation, optical microscopy and X-ray diffraction, and to the development of radar.
Wilkins received the Noble Piece Prize in 1962 for their work on the structure of DNA.
published his autobiography, The Third Man of the Double Helix, in 2003. Contribution to Our Understanding The results of Wilkins and Franklin's experiment contributed to our understanding of DNA structure because of how they had first provided the X-ray photo that showed that the DNA is a double helix shape. That photo was in fact used by Watson and Crick to discover more about the DNA. Rosalind Franklin was successful in discovering the possible structure of DNA shown on an x-ray diffraction photo
Watson and Crick first published this discovery before Franklin and Wilkins.
Franklin discovered the existence of the A and B forms of DNA
Developed method to separate the two forms
Discovered the helical structure of DNA has two strands, not three as previously proposed
Discovered that the sugar-phosphate backbone of DNA lies on the outside of the molecule, not the inside as was previously thought. Results Franklin discovered that DNA crystallizes into A-DNA and B-DNA
Find molecular structure: Wilkins - B-DNA, Franklin - A-DNA
Used x-ray crystallography X-ray crystallography Used to determine atomic and molecular structure of a crystal
DNA crystal exposed to x-ray beams
When deflected, produces a diffraction pattern (pattern of dark/light
Measure angle/intensity of beams deflected to determine electron density -> position of atoms
Photograph 51 - x-ray diffraction of DNA by Raymond Gosling who worked under Franklin
Showed double helix & sugar-phosphate backbone on outside of structure