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Brandi Kolata

on 27 February 2017

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Transcript of Hydrochlorothiazide

Purpose of Hydrochlorothiazide
Hydrochlorothiazide is a thiazide diuretic which is basically known as a water pill. This type of pill helps your body from absorbing too much sodium. This medicine is mainly used to treat high blood pressure. It often is combined with other medicines to help treat high blood pressure. But, it also could be use to treat fluid retention in people who may have heart failure, cirrhosis in the liver, or even kidney disorders.
Active/Inactive Ingredients
Inactive Ingredients: Silicon Dioxide, Magnesium Stearate, D&C Yellow 10, FD&C Blue 1, FD&C Blue 2, FD&C Red 40, Gelatin, Cellulose, Corn Starch, Propylene Glycol, Sodium Lauryl Sulfate, Ferrosoferric, Titanium Dioxide, Shellac,
Chemical/Physical Properties of Hydrochlorothiazide
Hydrochlorothiazide is a white colored, crystal powder that has no smell. Hydrochlorothiazide has a melting point of 273- 275 ° C and a boiling point of about 577 °C. It is slightly soluble in water and is completely soluble in ethanol or acetone. It has a density of 1.693 g/cm3. Pure Hydroclorothiazide could easliy catch on fire if stored in high temperatures
How Drugs Interact with the Body
When a drug enters the body it simulates receptors or proteins and the human body reacts in a certain way. Many of the drugs bind with proteins within the body, such as blood proteins or tissue proteins. Some of the drug binds to blood proteins, and the drug is kept in the blood. The free drug is either metabolized or it exits the body. Only the free drug can interact with receptors and create the therapeutic effect.
Side Effects
Blurred Vision/Vision Problems
Feeling weak/drowsy
Fast/Irregular Heartbeat
Muscle and Stomach Pains
Skin Rash
Loss of appetite
What it does to help achieve homeostasis
When the pill is taken, it enters the body and starts working. Hydroclorothiazide is known as a water pill, that causes you to urinate more. That helps to make your body get rid of the extra salt and water in the body. All the extra salt makes your body store extra water that ultimately makes you blood pressure go up. With this medication it tries to take the extra salt and water out of the body, so your blood pressure can lower back down to the normal range.
History of Hydrochlorothiazide
The first companies that tried to patent hydroclorothiazide in 1958 were Merck, Abbott, Ciba, Schering, Chinoin, and Loevens. Although all those companies were trying to get the patent, Ciba was the expected one to get the official patent of hydroclorothiazide. No one still had the patent for hydroclorothiazide, but Ciba had started marketing strategies to sell the medicine. Soon after Merck had the intentions to start selling the hydroclorothiazde under a new brand name of Hydrodiuril. Eventually both brands made it to the shelves, but Ciba was faster and had a 2 month advantage over Merck. But in the end Merck sold more of the product as they were known for other reputable medicines, leaving Ciba to rethink there ideas. Today hydroclorothiazide is sold by many companies, and there's even a generic hydroclorothiazide that is cheaper.
FDA Requirements for Drug Approval
The FDA requires any company wanting to sell a drug to test it first. The companies spend years testing the drug, making sure it is safe for human use. The companies must provide evidence that the drug is safe and is effective for its intended use to the FDA. FDA's Center for Drug Evaluation and Research (CDER) does not do research of its own on the drug, they just review the data that is presented by the company. After this review if the scientist determined that the drug's health benefits outweigh the risks of the drug, it is then approved for sale. The process of testing the drug, getting it approved by the FDA, and to the pharmacy shelves could take anywhere from 5 to 12 years.
Active Ingredient: Hydrochlorothiazide
APA Citations
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Hydroclorothiazide [PDF]. (n.d.). Retrieved from https://monographs.iarc.fr/ENG/

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Hydrochlorothiazide Supply. (n.d.). Retrieved from http://www.lookchem.com

Material Safety Data Sheet Hydrochlorothiazide MSDS. (n.d.). Retrieved from

New Drug Approval Process. (n.d.). Retrieved from https://www.drugs.com/fda-

Staff Report on Sales, Promotion, and Product Differentiation in Two Prescription
Drug Markets. (n.d.). Retrieved from https://www.ftc.gov/sites/default/files/documents/reports/sales-promotion-and-product-differentiation-two-prescription-drug-markets/197702salespromo.pdf

Ther, Austin. (2014, February 7). Protein Binding Drug-Drug Interaction between
Warfarin and Tizoxanide in Human Plasma. Retrieved from http://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v2-id1038.php

What is HCTZ. (n.d.). Retrieved from https://www.drugs.com/hctz.html


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