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A Computational Model of Cardiopulmonary Resuscitation
Transcript of A Computational Model of Cardiopulmonary Resuscitation
Solution - Computational Modeling Blood Volume
Vessel wall elasticity
Resistance - R
Inductance - L
Capacitance - C
Variable L,C, and R Put them together! Math Kick In! Cook the equations in Matlab %% Volume-defined pressure
p600(n+1) = V60(n+1)/C60+p_e;
p700(n+1) = V70(n+1)/C70+p_e;
p800(n+1) = V80(n+1)/C80+p_e;
% p850(n+1) = p_e+V85(n+1)/C85;
p850(n+1) = (QV85(n+1)*t_inc+Ptr850(n)*arrayC85(n+1))/(2*arrayC85(n+1)-arrayC85(n))+p_e;
p1100(n+1) = V110(n+1)/C110+(p_e+1/5*p1000(n+1)); % 7/2 EAS p_e added as requested by AN
p1200(n+1) = V120(n+1)/C120+p_e;
p1300(n+1) = V130(n+1)/C130;
p1350(n+1) = V135(n+1)/C135;
p1400(n+1) = V140(n+1)/C140; % 7/2 EAS p_e removed as requested by AN
% p1500(n+1) = p_e+V150(n+1)/C150;
p1500(n+1) = (QV150(n+1)*t_inc+Ptr1500(n)*arrayC150(n+1))/(2*arrayC150(n+1)-arrayC150(n))+p_e; Animal Experiments - not accurate Human Experiments - unethical Results - Textbook Realistic & Clinically Sound Heng 'Marshall' Yang 24Marshall@gmail.com Future Reference Blood distribution in the body American Heart Association, I. (2009). Cardiopulmonary Resuscitation (CPR) Statistics. Retrieved April 1, 2009, from http://www.americanheart.org/presenter.jhtml?identifier=4483
Babbs, C. F. (2003). Interposed abdominal compression CPR: a comprehensive evidence based review. Resuscitation , 71-82.
Frasch, H. F., Kresch, J. .., & Noordergraaf, A. (1998). Interpretation of coronary vascular perfusion. In G. M. Drzewiecki, & J. K.-J. Li, Analysis and assessment of cardiovascular function (p. Ch .7). New York: Springer.
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Noordergraaf, G. J., Dijkema, T. J., Kortsmit, W. J., Schilders, W. H., Scheffer, G. J., & Noordergraaf, A. (2005). Modeling in Cardiopulmonary Resuscitation: Pumping the Heart. Cardiovascular Engineering , 5 (3), 105-118.
Noordergraaf, G. J., Ottesen, J. T., Kortsmit, W. J., Schilders, W. H., Scheffer, G. J., & Noordergraaf, A. (2006). The Donders Model of the Circulation in Normo- and Pathophysiology. Cardiovascular Eng , 6, 53-72.
Palladino, J. L., Riberio, L. C., & Noordergraaf, A. (2000). HUman Circulatory System Model Based on Frank's Mechanism. In J. T. Ottesen, & M. Danielsen, Mathematical Modeling in Medicine (pp. 29-40). Amsterdam: IOS Press.
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Poul-Erik Paulev, M.D., D.Sci, Textbook in
Medical Physiology And Pathophysiology
Essentials and clinical problems
Copenhagen Medical Publishers 1999 - 2000
Gao et al, The Fifth Foresight Conference on Molecular Nanotechnology. November 5-8, 1997; Palo Alto, CA
Greater Cardiac output
Maintain vessel diameter
Time dependent Find a better CPR technique
Find the Difference! Round one Round two In CPR Major thoracic veins collapse
Occlude blood flow Certain signals open the veins People Supervisor: Abraham Noordergraaf
Team: Yi Gao, Evan Susanto