A Computational Model of Cardiopulmonary Resuscitation Problem - CPR is not effective Survival rate for reported cardiac arrests: 1% - 30% (American Heart Association, 2007)

With defibrillation

Solution - Computational Modeling Blood Volume

Blood Pressure

Blood Flow

Blood viscosity

Blood inertia

Vessel wall elasticity

Valves

Collapse Electrons

Voltage

Current

Resistance - R

Inductance - L

Capacitance - C

Diodes

Variable L,C, and R Put them together! Math Kick In! Cook the equations in Matlab %% Volume-defined pressure

p600(n+1) = V60(n+1)/C60+p_e;

p700(n+1) = V70(n+1)/C70+p_e;

p800(n+1) = V80(n+1)/C80+p_e;

% p850(n+1) = p_e+V85(n+1)/C85;

p850(n+1) = (QV85(n+1)*t_inc+Ptr850(n)*arrayC85(n+1))/(2*arrayC85(n+1)-arrayC85(n))+p_e;

p1100(n+1) = V110(n+1)/C110+(p_e+1/5*p1000(n+1)); % 7/2 EAS p_e added as requested by AN

p1200(n+1) = V120(n+1)/C120+p_e;

p1300(n+1) = V130(n+1)/C130;

p1350(n+1) = V135(n+1)/C135;

p1400(n+1) = V140(n+1)/C140; % 7/2 EAS p_e removed as requested by AN

% p1500(n+1) = p_e+V150(n+1)/C150;

p1500(n+1) = (QV150(n+1)*t_inc+Ptr1500(n)*arrayC150(n+1))/(2*arrayC150(n+1)-arrayC150(n))+p_e; Animal Experiments - not accurate Human Experiments - unethical Results - Textbook Realistic & Clinically Sound Heng 'Marshall' Yang 24Marshall@gmail.com Future Reference Blood distribution in the body American Heart Association, I. (2009). Cardiopulmonary Resuscitation (CPR) Statistics. Retrieved April 1, 2009, from http://www.americanheart.org/presenter.jhtml?identifier=4483

Babbs, C. F. (2003). Interposed abdominal compression CPR: a comprehensive evidence based review. Resuscitation , 71-82.

Frasch, H. F., Kresch, J. .., & Noordergraaf, A. (1998). Interpretation of coronary vascular perfusion. In G. M. Drzewiecki, & J. K.-J. Li, Analysis and assessment of cardiovascular function (p. Ch .7). New York: Springer.

Kouwenhoven, W., Jude, J., & Knickerbocker, G. (1960). Closed Chest Cardiac Massage. JAMA , 173:1064 - 7.

Mokdad, A. H., Marks, J. S., & Stroup, D. F. (2004). Actual Causes of Death in the United States, 2000. JAMA , 1238-1245.

Noordergraaf, A. (to be published ). Blood in Motion. Verlag, NY : Springer .

Noordergraaf, G. J., Dijkema, T. J., Kortsmit, W. J., Schilders, W. H., Scheffer, G. J., & Noordergraaf, A. (2005). Modeling in Cardiopulmonary Resuscitation: Pumping the Heart. Cardiovascular Engineering , 5 (3), 105-118.

Noordergraaf, G. J., Ottesen, J. T., Kortsmit, W. J., Schilders, W. H., Scheffer, G. J., & Noordergraaf, A. (2006). The Donders Model of the Circulation in Normo- and Pathophysiology. Cardiovascular Eng , 6, 53-72.

Palladino, J. L., Riberio, L. C., & Noordergraaf, A. (2000). HUman Circulatory System Model Based on Frank's Mechanism. In J. T. Ottesen, & M. Danielsen, Mathematical Modeling in Medicine (pp. 29-40). Amsterdam: IOS Press.

The New Zealand official year-book. (1906-2006). Wellington, N.Z.: Govt. Printer.

Poul-Erik Paulev, M.D., D.Sci, Textbook in

Medical Physiology And Pathophysiology

Essentials and clinical problems

Copenhagen Medical Publishers 1999 - 2000

Gao et al, The Fifth Foresight Conference on Molecular Nanotechnology. November 5-8, 1997; Palo Alto, CA

Greater Cardiac output

Maintain vessel diameter

Time dependent Find a better CPR technique

Find the Difference! Round one Round two In CPR Major thoracic veins collapse

Occlude blood flow Certain signals open the veins People Supervisor: Abraham Noordergraaf

Team: Yi Gao, Evan Susanto

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# A Computational Model of Cardiopulmonary Resuscitation

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