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Transcript of STEM CELL
AFSC Uses Gelatinous Protein Mixture Valproic Acid - not adding foreign genes HOW iPS and AMNIOTIC REPROGRAMMED EMBRYONIC CELL
COME FROM Stem Cell Research HOW TO KNOW A STEM CELL AMNIOTIC FLUID HOW TO KNOW A STEM CELL CONT: Stem Cell Will Light Up Under Fluorescent Light Sample Tissues for Initial Culture of own patient Avoids Immune Rejection No Ethnical Issues ADULT STEM CELLS DISADVANTAGES Advanced Adult Reprogrammed iPS STEM CELLS DISADVANTAGES iPS STEM CELLS Reprogramming- Cell, Virus Efficiency Tendency to Produce Tumors Adult Cell Reprogrammed to
Induced Pluripotent Tissue From Same Patient Rec-Avoid Rejection Multiplying Indefinitely In Vitro No Ethnical Issues ADVANTAGES Can't Multiply Indefinitely in Lab Not Pluripotent Naturally Tendancy to Create Tumors Difficult to Cultivate In Vitro Then Molecules Bind with
Chemical Messages of Receptors Unique Proteins- Receptors Chemical Messages Bind to Receptors Identify Receptors Then Tag Them Fluorescent Molecules EMBRYONIC STEM CELL ADVANTAGES Ability to Form All Cells of
Adult Body-Pluripotent Cultivating Indefinitely In Vitro Standard for Stem Cells EMBRYONIC STEM CELL DISADVANTAGES Exists Only in Early Stages Potential to Develop Tumors Possible Immune Rejection Very Controversial AMNIOTIC STEM CELLS ADVANTAGES Grow Indefinitely In Vitro Reprogram to Pluripotent Do Not Create Tumors No Ethnical Issues Cell Banks AMNIOTIC STEM CELLS DISADVANTAGES Has to be programmed All STEM CELLS HAVE THERE PLACE: Amniotic Fluid Stem Cell WHAT CLASSIFIES A STEM CELL Non-specialized (undifferentiated) cell
which is capable of two processes: A STEM CELL CONT: Self Renewal Differentiation- TISSUE SPECIFIC Fluid that Surrounds the Fetus
in Sac "water breaks" Essential Development-
Fluid is "inhaled" and "exhaled" If Scientist can reliably direct the differentiation of many types of stem cells into specific types, they may be able to use them to treat all type of diseases in the future. Logically the need for stem cell research is definitely needed for the betterment of medicine, However, at this point in time until further advancements, the amniotic stem cell may be the best route to take for continued research because of their stability of not becoming tumorgenic. Lastly, the amniotic stem cell is one of the cells chosen to support stem cell banks in the United States and Europe EMBRYONIC STEM CELLS Pluripotent Inner Cell Mass of
Blastocyst, 4-5 days Destruction of Embryo Differentiate- All Cells-3 Germ Layers: ectoderm, endoderm, and mesoderm. ADVANTAGES ADULT STEM CELLS Protects Baby in Abdomen ADULT STEM CELL Specialized Cells
(Differentiated) Adult, Children, and Fetuses Only Tissue of Origin ADULT STEM CELLS CONT: Primary Role- Maintain
and Repair Tissue of Origin Only One Adult Stem Cell
For Every 100,000
Surrounding Cells (watson, freudenric, 2013) ADVANTAGES AMNIOTIC CELLS CONT: (Atala, 2007) Only 1% are Stem Cells All Types, more specialized watson, freudenrich, 2013 Not Naturally Pluipotent Valproic Acid-FDA medication for
mood, seizures... now used in iPS EMBRYONIC ADULT iPS AMNIOTIC FLUID Amniotic stem cell appears to be the safest and successfully stem cell to transplant to a host that are not donor related. Like adult stem cell transplants, this can still be a problem that exists with organ recipient’s body accepting the transfer even if the donor is a match. One possible reason for this is that amniotic epithelial cells have low antigen levels that inhibit compatibility from a donor to the recipient. Antigens relate to any substance that stimulates an immune response in the body. Also, amniotic epithelial cells are known to promote natural wound healing (Liu YH, Vaghjiani V, Tee JY, To K, Cui P, et al., 2012). National Center for Biotechnology Information. U.S. National Library of Medicine, (NATIONAL INSTITUTE OF HEALTH, n.d. Web. 03 Feb. 2013). ("HOPES." HOPES. N.p., n.d. Web. 17 Feb. 2013).
"What Are Stem Cells." N.p., n.d. Web. Science Resources. N.p., n.d. Web. 17 Feb. 2013. (Alternatives to Embryonic Stem Cells. N.p., n.d. Web. 17 Feb. 2013.)Harvard Stem Cell Institute Harvard Stem Cell Institute (Harvard Stem Cell Institute,Web. 17 Feb. 2013.) THIS STEM CELL APPEARS TO BE SAFEST
AND MOST SUCCESSFULLY TO TRANSPLANT
TO HOST NOT DONOR RELATED. KNOW TO PROMOTE NATURAL HEALING Liu, Yu Han, Vijesh Vaghjiani, Jing Yang Tee, Kelly To, Peng Cui, Ding Yuan Oh, Ursula Manuelpillai, Ban-Hock Toh, and James Chan. Centre for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Victoria, Australia NUMEROUS SCIENTISTS AT DEPT OF MEDICINE IN AUSTRALIA DOCUMENTED RELATING: Majority of Advantages Do Not Create
Tumors Are Readily Available-Discard (Watson,Freudenrich, 2007) Diane Black