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The Paris System for Reporting Urinary Cytology

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Juan Santa Rosario

on 2 June 2016

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Transcript of The Paris System for Reporting Urinary Cytology

Bladder Cancer - more than one disease?
~75% Non-muscle invasive (Ta/T1)
Good prognosis

~25% Muscle invasive (>T2)
>60% overall survival
Negative for High-Grade Urothelial Carcinoma
The Paris System for Reporting Urinary Cytology
High-Grade Urothelial Carcinoma
System built based on:
In the absence of atypical or malignant cells, obscuring inflammation/lubricant an adequate bladder barbotage specimen should have a minimum of

(20 per 10 hpfs) well-visualized, well-preserved urothelial cells to increase positive predictive value of this test.
Volume is an important component in the evaluation of adequacy for voided urine cytology specimens (30mL).
The Quest for Standarization
Cervical , Thyroid and Pancreatic Cytology Success
The Bethesda System, LAST project

Improve communication
Improve patient management
Atypical Cells
Wide intraobserver variability
Rates of atypical vary among institutions
Range from 2%-30%

Urothelial Carcinoma
Atypical Urothelial Cell (AUC)
Ancillary Studies in Urinary Cytology
Total urothelial cells lining the bladder is in the order of 10-10 cells.
8 9
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