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Seminar Presentation: DNA Drugs Come of Age

By: Adriana Shu-Yin, Dorothy Tang, Joyce Ng, and Tudor Chirila


on 3 October 2012

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Transcript of Seminar Presentation: DNA Drugs Come of Age

By: Adriana, Dorothy, Joyce, and Tudor DNA Drugs Come of Age Background
Plasmids: induces immune response Introduction more immune cells can take up more plasmids from the vaccine Improvements

no cure for HPV tumors or Hepatitis-C YET! Other Uses plasmid: small rings of DNA that can replicate independently of chromosomes

plasmids transfer genes into the cell that makes the cell manufacture the protein How It Works

plasmids can be reused, without the body developing immunity Pros & Cons (cc) image by nuonsolarteam on Flickr Pros Cons
function Discovery of: DNA can be used for: Plasmid Vaccines vs Adenovirus Vaccines Future for DNA Virus How It Works carries a gene for a pathogen (virus)
codon optimization- choosing the best sequence of DNA to increase the amount of proteins to boost the effectiveness of a vaccine. Improvements medicines Adenovirus: directs attention to pathogens Despite initial failure, plasmid vaccines show success in labs does not code for the entire pathogen transfection: plasmids enter a host cell
antigen: (protein) foreign substance to stimulate immune response may not work and even have adverse effects transdermal patches, Gene Gun, and Biojects
Each amino acid is categorized by 3 sets of DNA letters that make up one codon
Adjuvants: added to a regular vaccine to increase immune system response stable at room temperature (no need for refrigeration) faster manufacture and production safe in transferring genes into cells potential for other treatments avoids complications DNA biological immunotherapy one vaccine can account for different types of the same virus DNA vaccines have the ability to target any specific problem ability of preventing epidemics/pandemics TEST YOUR KNOWLEDGE! Plasmid VS. Adenovirus Electroporation: electrical currents applied through the skin to make temporary holes in a membrane

placebo shot - 0.03% Adenovirus Setbacks STEP trials two HIV negative groups real shot - 0.05% structure location vaccines therapies application Vaccine
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