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Nanotechnology in Immunology

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by

Paul Lai

on 6 May 2014

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Transcript of Nanotechnology in Immunology

How vaccines and nanotech combine
Delivery of antigens via nanoparticles
The Future and Beyond?
the Dynamic Duo
The mailman of cells
Immunostimulatory Nanovaccines
Nanoparticles acts as a protective capsule, separating antimicrobial agents from the body
$46.67
Tuesday, March 6, 2014
Paul Lai
"To catch a criminal, send a criminal..."
Why Nanotech?
Nanoscale Immune Activation
Nanotechnology in Immunology
The what, how, and why of VLPS
ITS A VIRUS!....Kind Of
VLPs are diverse and highly versatile nanoparticles (20–100 nm in size) that have been used in vaccines against infectious diseases and cancer
VLPs can be distinguished from viruses by their absence of genetic material and their inability to replicate or to undergo genetic recombination.
Several of the advantages of using VLPs and other nanoparticles in vaccines are related to the unique nanodimensional size, symmetrical shape, uniformity and stable structure of the assembled nanoparticles, which closely resemble native viruses.
Nanotherapeutics
- Exploits properties of substances at the size range of 1–1,000 nanometres

- nanostructures can be used to more effectively manipulate or deliver immunologically active components to target sites

-enables creation of new generations of vaccines, adjuvants and immunomodulatory drugs that aim to improve clinical outcomes in response to a range of infectious and non-infectious diseases.
$46.67
Tuesday, March 6, 2014
Vol XCIII, No. 311
Relevant Diagrams
How Does Nanotechnology alter the induction of immune responses?
Can be modified to be cell specific
Vaccines usually incorporate adjuvants
Nanoparticles provide adjuvant activity by enhancing the delivery of antigens to the immune system or by potentiating innate immune responses.
Nanoemulsions fuse with lipid-containing cells
Depot effect promotes the persistence, the stability, the conformational integrity and the gradual release of vaccine antigens
"...spatial organization of the antigens on the particle surface facilitates B cell receptor (BCR) co-aggregation, triggering and activation..."
"...Nanoparticle mediated leakage of antigens into the cytosol after they have been taken up by the phagosome..."
Nanoscale Immunosuppression
antigen presenting cells
deliver compounds that result in immunosuppression
upregulation of transforming growth factor-β
delivery of immunosuppressants
antigen presenting cells
immunostimulation
upregulation of homing receptors
Enhanced delivery of antigens and adjuvants
specific immune responses for prophylactic and therapeutic effects
Improved protection against the outbreak of pandemic viruses and other emerging or mutating pathogens
selective perturbation of the immune response
'suppressive nanoparticles' could be given to relatives of patients with specific autoimmune diseases in order to prevent disease development
The Future of Nanotechnology in Immunology
Thanks for listening!
Fullerenes
molecules that are exclusively composed of carbon and that are commonly used in nanotechnology in the development of items such as electronics, paints and polymer composites
treatment prevents histamine release and prevents the reduction in body temperature after allergen encounter
Full transcript