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GLUTATHIONE

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by

Ronelle Risha Mariano

on 11 January 2015

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Transcript of GLUTATHIONE

GLUTATHIONE PROCESS
RedOx equation explained by Risha Mariano 3-D
The paper itself
Under
Pharmacology
Argument: GSH/GSSG redox potential are dependent on
enzymes
Nerst Equation is disproven
The GSH/GSSG redox reaction
What is Glutathione??
mother of all antioxidants, the master detoxifier and maestro of the immune system

C
10
H
17
N
3
O
6
S
What are the recent forms of Glutathione?
Redox Regulation by Glutathione needs enzymes
GSH - reduced Glutathione (the absorbable form)
Glutathione (SH-)
[thiols]
attached Sulfur-Hydrogen ion
GSSG - oxidized Glutathione
Glutathione Disulfide
BENEFITS
Commercial Purpose?
glutathione inhibits the synthesis and agglutination of melanin
Natural Glutathione
Problem: Reaction is too slow
REVIEW: Redox
The goal is to attain EQUILIBRIUM
when can I see the results?
medium brown: 1-3 months

• • dark brown skin: 3-6 months

• • very dark skin: 6-12 months.

• • black skin: at least 2 years or even more

• • Once a person has her desired skin color, the maintenance dose will just be 500mg once a day.

DYK: Oral Glutathione isn't very effective
NADH/ NADP makes the GSH/GSSG attain equilibrium
but it is slow.
when NADH/NAD gets replaced by NADPH/ NADP
also known as GSR
the enzyme to catabolize the NADPH/NADP attainment of equilibrium with the GSH/GSSG couple
a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell.
initially:
Any of a class of organic chemical compounds similar to the alcohols and phenols but containing a sulfur atom in place of the oxygen atom.
What is Glutathione?
needs enzymes to catabolize reaction
how about Vitamin C?
Ascorbate and glutathione play central roles in the defense against free radicals and oxidants that are implicated in chronic diseases.
The Nernst Equation enables the determination of cell potential under non-standard conditions
Application: a hands-on experimental environment is more reliable than a virtual environment even with specific calculations
Redox Regulation by Glutathione needs enzymes
Carsten Berndt
- Department of Neurology,
Medical Faculty
Heinrich-Heine University Dusseldorf, Germany
Christopher H. Lilig
-Institute for Medical Biochemistry and Molecular Biology, University Medicine
Ernst-Moritz-Arndt University, Greifswald, Germany
Leophald Flohe
- Departamento de Bioquimica
Universidad de la Republica Montevideo, Uruguay
- Department of Chemistry
Univeristy of Padova, Padova, Italy

AUTHORS
Edited by:
Alfonso Pompella
Universita di Pisa, Italy

Reviewed by:
Jose A. Traverso
University of Granada, Spain
Tetsuro Ishii
University of Tsukuba, Japan
KEYWORDS on the article
Glutathione
- prevents damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides
Thermodynamics
- a branch of physics concerned with heat and temperature and their relation to energy and work
Kinetics
- is the study of rates of chemical processes.
Enzyme
- are biological molecules (proteins) that act as catalysts and help complex reactions occur
Redox Signaling
- is the concept that electron-transfer processes play a key messenger role in biological systems.
Charles Darwin arguably provides the first illustration ( melanin is a free radical )
Full transcript