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practical pharmacology

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by

asmaa ali

on 12 February 2017

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Transcript of practical pharmacology

practical pharmacology
1- Chloral hydrate
FROG
MOUSE
1 - Species :
Frog
2 - Sex :
male or female
3 - weight :
in grams ( gm )
4 - Dose calculations :
HOW ??
5 - Route of Administration
S.C.
6 - General Health
1 - vitality
before administration :
after administration
NORMAL
DECREASED
2 - EXCITABILITY
before administration :
after administration :
normal
decreased
3 - R.R. :
4 - H.R. :
before administration
after administration
100 breath/min
60 breath /min
120 beat/min
90 beat/min
the units are v.imp.
5 - Gait :
normal
STAGGERING gait
بت
6 - Posture :
normal
head
downward
7- Eye ball

8- Eye pupil
before administration
after administration
----------
----------
normal
miosis
why ??
9 - Reflexes
a) Pain :
present
present but
depressed

b) touch :
c) light :
d) corneal :
present
present
e) righting reflex :
present
absent
= loss of righting reflex
the key of identification
10 - secretion :

lacrimation
salivation
sweating
---------
---------
before administration
after administration
11 - excretion
urination
defecation
---------
---------
before administration
after administration
7 - Onset of time :
30 - 45 min.
8 - pecularities :
any change that
occurs due to
the drug :)
loss of righting reflex (
THE KEY
)
vitality, excitability, R.R., and H.R are decreased
staggering gait
head downward
miosis
pain and touch reflexes are present but depressed
9 - conclusion :
3 main points ;)
group :
subgroup :
drug :
CNS acting drug
CNS depressant
( sedative, hypnotic )
MAY BE :
chloral hydrate
2- Chlorpromazine ( CPZ )
1 - Species :
mouse
2 - Sex :
male or female
3 - weight :
in grams ( gm )
4 - Dose calculations :
HOW ??
5 - Route of Administration
I.P.
6 - General Health
1 - vitality
before administration :
after administration
NORMAL
DECREASED
2 - EXCITABILITY
before administration :
after administration :
normal
decreased
3 - R.R. :
4 - H.R. :
before administration
after administration
300 breath/min
250 breath /min
500 beat/min
600 beat/min
the units are v.imp.
5 - Gait :
normal
creeping gait
بت
6 - Posture :
normal
abdomen touches the ground
7- Eye ball

8- Eye pupil
before administration
after administration
----------
----------
normal
normal
why ??
9 - Reflexes
a) Pain :
present
present but
depressed

b) touch :
c) light :
d) corneal :
present
present
e) righting reflex :
present
10 - secretion :

lacrimation
salivation
sweating
---------
---------
before administration
after administration
11 - excretion
urination
defecation
---------
---------
before administration
after administration
why is the heart rate increased with chlorpromazine ??
2 reasons
CPZ is alpha-1 blocking agent :

vasodilation
decrease blood pressure
reflex tachycardia
CPZ has anti-cholinergic effect :
anti-muscarinic
atropine like action
----
----
present
9 - conclusion :
3 main points ;)
group :
subgroup :
drug :
CNS acting drug
CNS depressant
( antipsychotic -
major tranquilizer )
MAY BE :
chlorpromazine
8 - pecularities :
any change that
occurs due to
the drug :)
state of catalepsy (
THE KEY OF CPZ
. )
vitality, excitability, and R.R. are decreased
H.R. is increased
creeping gait
abdomen touches the ground
7 - Onset of time :
15 min.
STATE OF CATALEPSY :

1- decrease in muscle tone
2- sustained immobility
3- loss of grip strength
4-state of indifference
Practical Pharmacology 2
ك:)
General Scheme
1 - Species :
Frog (amphibian)
Mouse (mammalian)
2 - Sex :
male or female
3 - weight :
in grams ( gm )
4 - Dose calculations :
HOW ??
5 - Route of Administration
S.C.
6 - General Health
1 - vitality
before administration
after administration
NORMAL
2 - EXCITABILITY
3 - R.R. :
4 - H.R. :
frog : 100 breath/min
mouse : 300 breath/min
frog: 120 beat/min
mouse: 500 beat/min
the units are v.imp.
normal
6 - Posture :
normal
9 - Reflexes
a) Pain :
present
present but
depressed

present but
exaggerated

b) touch :
e) righting reflex :
present
- present , or
- absent
= loss of righting reflex
10 - secretion :

lacrimation
salivation
sweating
---------
---------
increase:
pilocarpine
before administration
after administration
11 - excretion

urination
defecation
---------
---------
increase:
pilocarpine
before administration
after administration
7 - Onset of time :
Frog : 30 - 45 min.
8 - peculiarities :
any change that
occurs due to
the drug :)
9 - conclusion :
3 main points ;)
group :
subgroup :
drug :
CNS acting drug
Autonomic acting drug
- CNS:
depressant - stimulant

- sympathomimetic -
parasympathomimetic
MAY BE :
-----------
I.P.
Mouse : 15 min.
normal
increased:
CNS stimulant
decreased:
CNS depressant
5 - Gait
increased or decreased ( with numbers )
staggering: chloral hydrate
rapid: caffeine
creeping: CPZ
arched shape: strychnine
head downward: chloral hydrate
abdomen touch the ground: CPZ
7- Eye ball
8- Eye pupil
the pattern of movement of the limbs.
the shape of the body while standing
frog:
Mouse
before:
after:
----------
----------
why?
normal
normal- protrusion
frog
mouse
before:
after:
normal
normal - mydriasis
miosis
---------
---------
why?
c) light:
from the pupil
frog:
mouse:
before:
after:
present
-------
present
lost: atropine
-------
d) corneal:
before:
after:
present
present
lost: local anesthesia
present
Full transcript