Send the link below via email or IMCopy
Present to your audienceStart remote presentation
- Invited audience members will follow you as you navigate and present
- People invited to a presentation do not need a Prezi account
- This link expires 10 minutes after you close the presentation
- A maximum of 30 users can follow your presentation
- Learn more about this feature in our knowledge base article
Do you really want to delete this prezi?
Neither you, nor the coeditors you shared it with will be able to recover it again.
Make your likes visible on Facebook?
You can change this under Settings & Account at any time.
Transcript of suga
The first selective relaxant binding agent (SRBA)
Sugammadex (tradename Bridion)
rocuronium, vecuronium, and pancuronium in that order
Does not have affect atracurium or cisatracurium
operates with aminosteriod agents not benzylisoquinoline agent
indicated for the reversal of neuromuscular blockade by rocuronium or vecuronium
a modified gama-cyclodextrin
lipophilic core and a hydrophilic periphery
has negatively charged carboxyl thio extensions that electrostatically bind to the positively charged ammonium group of the NMBD
NMBD molecule (a modified steroid) bound within sugammadex's lipophilic core, is rendered unavailable to bind to the acetylcholine receptor at the neuromuscular junction, bound in a ratio of one sugammadex molecule to one molecule of the NMBA
causes a concentration gradient and any remaining rocuronium or vecuronium molecules are attracted back into the plasma and become bound to free sugammadex molecules
Benefits of Sugammadex
Reversal of NMBD without effecting acetylcholinesterase
Cardiovascular and autonomic stability
Short duration and fast onset
Renally excreted with no metabolites
Elimination 1/2 life is 1.8 hours
>90% of dose excreted within 24 hours
2mg/kg for children >2 to <17
Adults >18: 4mg/kg for deep blockade or 2mg/kg for moderate blockade
For immediate reversal max dose of 16mg/kg