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Glucocorticoids

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by

Thushana Bremachandran

on 9 January 2013

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Transcript of Glucocorticoids

target organ target adrenal corticoid steroid CIRCULATORY SYSTEM VEHICLE: Corticoider undercover as:
Glucocorticoid shhhh....... aliases corticoid corticoidsteroid COSTUME aka molecular structure birthplace adrenal cortex HIDEOUT zona fasciculata stimulate gluconeogenesis
in liver extrahepatic : outside the liver Mobilize amino acids from extrahepatic tissues: These serve as substrates for gluconeogenesis. main adipose tissue Stimulation of fat breakdown how it signals with the targets: steroid hormone Primary function: stimulate tissues to raise blood glucose and break down protein the secreted glucocorticoids from the zona fasciculata, then travels through the circulatory system these glucocorticoids then attach themselves to the glucocorticoid receptors which are found on almost every cell a glucocorticoid receptor binds to glucocorticoids within the bloodstream, which allows the GCs to enter into the intercellular fluid of a cell the receptors are then transferred to the nucleus, where they perform specific functions depending on which glucocorticoid receptor was activated and which hormone was present superpowers surpress overactive immune system GC's travel through the blood until it reaches the inflammated area and then starts to break down the overactive immune system cells to stop inflammation Weaknesses suppression of the immune system surpression of calcium absorption inhibition of bone formation development of diabetes increase in cortisol= Cushing's syndrome cushing's disease in dogs negative feedback loop cortisol overview: when glucose levels drop in blood
due to... •skipping meals and snacks
•not eating enough food at a meal or snack
•exercising longer or harder than usual without eating some extra food
•getting too much insulin
•not timing the insulin doses properly with meals, snacks, and exercise
hypothalamus receives a signal
creates a releasing factor : CRH CRH signals the anterior pituitary gland to secrete ACTH ACTH then signals the adrenal cortex to produce and secrete the glucocorticoids targets liver inhibition of glucose uptake in muscle and adipose tissues Alternative functions: serves as an antiflammatory agent maintain homeostatis by regulating blood sugar levels if produced at safe amounts by body fetal development delayed wound heaing
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