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Cis-AB mutation Makes it Possible for Mother with AB Blood Type to give Birth to O Children

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Annie Hulsey

on 11 March 2013

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Transcript of Cis-AB mutation Makes it Possible for Mother with AB Blood Type to give Birth to O Children

CIS-AB Mutation
Makes it Possible for Mother with AB Blood Type to give Birth to O children By Annie Hulsey Blood is made up of red and white blood cells, platelets and plasma.
Blood types are located on chromosome 9.
Blood types are determined because of:
Type A- with A antigens on the red cells and anti B antibodies in the plasma.
Type B- with B antigens on the red cells and anti A antibodies in the plasma.
Type AB- both A and B antigens on the red cells and no blood type antibodies in the plasma.
Type O- with no antigens on the red cells and both anti A and anti B antibodies in the plasma.
Antibodies are blood proteins used to counteract antigens.
Antigens are a substance that causes an immune response or even possibly the production of antibodies.
A and B are the dominant alleles and O is recessive.
There is one base difference between A and O and seven between A and B.
A point mutation is when a single base pair is altered in the gene sequence.
Platelets form clots.
Red blood cells carry oxygen.
White blood cells fight infection.




Basically this mutation allows the mother to pass on either AB or O because of her double trait in the single allele. It would make it possible for both kids to be O because of the 50% chance as well as the fact that cis-AB would last forever and not disappear within the 6 years of the two children's birth. Works Cited "Annals of Clinical & Laboratory Science." A Novel Cis-AB Allele Derived from the A Transferase Gene by Nucleotide Substitution C796A. N.p., n.d. Web. 04 Mar. 2013.
"Blood." : Platelets. N.p., n.d. Web. 04 Mar. 2013.
"Blood Disorder Types, Symptoms, and Treatments." WebMD. WebMD, n.d. Web. 04 Mar. 2013.
"Â ." Blood Groups, Blood Typing and Blood Transfusions. N.p., n.d. Web. 04 Mar. 2013.
"Blood_types." Blood_types. N.p., n.d. Web. 04 Mar. 2013. "Chromosome 9: Gene for Blood Group, Matt Ridley :: DNA Learning Center." DNALC Blogs. N.p., n.d. Web. 04 Mar. 2013.
"The Cis-AB Blood Group Phenotype: Fundamental Lessons in Glycobiology." Transfusion Medicine Reviews. Elsevier Inc., n.d. Web. 20 Feb. 2013.
Cuschieri, A. "Muations." Department of Anatomy University of Malta, n.d. Web. 19 Feb. 2013.
"Incidence of a Type AB Infant Born to a Type O Mother." Incidence of a Type AB Infant Born to a Type O Mother. N.p., n.d. Web. 04 Mar. 2013.
"Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 04 Mar. 2013.
"Sandwalk." : Genetics of ABO Blood Types. N.p., n.d. Web. 06 Mar. 2013.
"Transfusion for a Patient of Cis-AB Blood Type Undergoing a Redo Cardiac Operation." Oxford Journals. The Board of Management and Trustees of the British Journal of Anaesthesia, 5 Mar. 2005. Web. 18 Feb. 2013.
"Understanding Genetics." Understanding Genetics. N.p., n.d. Web. 04 Mar. 2013.
"What Is a Blood Transfusion?" - NHLBI, NIH. N.p., n.d. Web. 04 Mar. 2013. Background Information The Problem In this scenario, a mother with AB blood gives birth to two children (born 6 years apart) with O blood. However, O blood type is a recessive gene so it is not possible for the AB (both A and B are dominant) mother to have kids with that phenotype even if the father is also O blood. “The cis-AB phenotype can raise questions about an apparently paradoxical inheritance of the ABO blood group, such as the birth of an O child from an AB mother.” -NCBI
Brainstorming Blood Types Conclusion of Data Sketches Our group came up with 3 possible solutions:
Cis-AB mutation
Egg donor
Surrogacy Trait- Blood Type
Allele- I -A blood, I -B blood, i-O blood
Parents- mutated AB x homo. O However....
We were told that the mother gave birth and conceived the children herself (and is genetically related to both children) so the last two were out of the picture. Plus when we explored mutations, we found this option, and it seemed likely to happen twice. What is cis-AB mutation? Blood Type Possibilities I I A B i i i ii ii I I i I I i A B A B 50% chance! A B I I i ii A B Mutated AB/I I i- 2/4
Homo. O/ii- 2/4 A B When one parent carries the Cis-AB allele, the other allele it carries could be either A, B, or O, but the phenotype of the parent is still AB. The children can inherit an abnormal blood type like the parent’s AB blood type or another different allele it carries in its genes (A, B, or O). There possible ways that this mutation can occur: Nucleotide substitution- on A allele on codon 268 Nucleotide Substitution- on B allele on codon 266 Point Mutation- on B transferase (various proteins that start up the transfer of a chemical group, like phosphate, from one molecule to another) gene on codon 234 A rare ABO genotype that creates a mutated gene resulting in one allele that expresses both A and B. This mutation does not follow Mendel's basic laws of inheritance.
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