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Hepatitis B protection by the Yeast Saccharomyces cerevisiae

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on 4 November 2014

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Transcript of Hepatitis B protection by the Yeast Saccharomyces cerevisiae

Hepatitis B protection by the Yeast Saccharomyces cerevisiae
What is Hepatitis B?
Hepatitis B is transmitted in the blood infected during intravenous drug use
sex with people who are infected
infected mother to her newborn during the delivery process.

Saccharomyces cerevisiae
is a species of yeast. It is the most useful yeast, having been instrumental to winemaking, baking.

due to the fact that its genome has been sequenced, its genetics are easily manipulated.

fungus protect us from Hepatitis B

By making this fungus a factory that manufactures one of the essential proteins of the virus and help the body in producing antibodies to this protein ..

Hepatitis B vaccine
The hepatitis B vaccine is safe and effective and is usually given as 3-4 shots.

The HBV vaccine became the first to be produced using recombinant DNA technology (1986)
Produced in bakers’ yeast (Saccharomyces cerevisiae)

People should remain at the doctor’s office for about 15 minutes after getting the vaccine.

How the vaccine is made??
by making an immune response.

By cleaving the gene responsible for secreting the surface protein of the virus which is hepatitis B surface antigen (HBsAg), and add it to the DNA sequance of Saccharomyces cerevisiae yeast.

The yeast cells then produce many copies of the protein .

Subunit Vaccines: Recombinant
made by injecting part of viral to which the immune system responds.

Hepatitis B is the world’s most common serious liver infection.

caused by the hepatitis B virus (HBV) that attacks liver cells and
can lead to liver failure, cirrhosis or cancer of the liver .
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