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Inflammatory Response

Health Occupations 3-4

James Vuong

on 22 October 2012

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Transcript of Inflammatory Response

Response By:
James Vuong
Jessica Tang Response Process:
Inflammation Mediators After the
Inflammation Response Tissue Repair Regeneration Replacement Inflammatory response to Mechanical Injury Did You Know? Definition History Response! What Is It? Nonspecific immune process produced in response to injury and resulting in redness, pain, heat, and swelling and promoting movement of white blood cells to the affected area. Any tissue injury including:
- Cuts
- Burns
- Chemicals
- Radiation
- Toxin released by Bacteria Described almost 2000 years ago by a Roman physician.

If patients displayed symptoms of any of the following:
- fever
- hypothermia
- tachycardia
- tachypnea
- abnormal white blood cell count

These were signs of inflammation. Inflammation Mediators - Chemicals released by irritated tissues that activate the inflammatory response - They cause blood vesicles to dilate (widen), increasing blood volume in tissue.
- They increase the permeability of blood vessel walls
- They act as signals that attract white blood cells to the injury site When the inflammatory response is intense aspirin or antihistamines can be used to disrupt the body's inflammation mediators - Inflammation will eventually eliminate irritant, thus allowing tissue repair to begin.
- Tissue repair: the replacement of dead cells with new living cells
-Two types of tissue repair:
- Regeneration
- Replacement - The growing of new cells similar to the one they replace
- Renewal of the tissues that have been damaged physically - The growing of new cells that are not similar to the ones they replace
- Results in a scar

- Fibrosis: a condition in which fibrous tissue replaces the old tissue

- most tissue repairs are a combination of regeneration and replacement Simply Stated It is a combination of processes in the human body that attempt to minimize injury to tissues. This is used to maintain homeostasis. 4 Primary Signs - Redness
- Heat
- Swelling
- Pain What is an
Inflammation Mediators? Functions of
Inflammation Mediators Inflammatory Mediators
and Blood Vesicles - Increased blood volume redness and heat of inflammation occurs
- It allows immune system cells (white blood cells) to travel faster and in a more efficient way to the site of injury. Increased Permeability of Blood Vessels - Allows immune system cells and other blood components to move out of the blood vessels easily so they can work on injured tissue

Edema - When water leaks out of vessel (tissue swelling)
- This triggers pain receptors, consciously alerting individual of damage

Inflammatory Exudate - Excess fluid that accumulates in the inflamed tissue and dilutes the irritant
- Removed by lymphatic vessels and carried to lymph node. Signals that attract
White Blood Cells Chemotaxis - Movement of white blood cells in response to chemical attractants

Phagocytosis - Known as cell eating, when white blood cells consume damaged cells and pathogenic bacteria

Pus - Forms when inflammatory exudate becomes thick with white blood cells, dead tissue and bacteria cells, and other debris QUIZ 1) What are the four primary signs of Inflammatory Responses?

2) What are the different responses of Inflammation Mediators?

3) What can be used to interrupt the body's Inflammation Mediators? ANSWERS 1) Redness, Heat, Swelling and Pain
- They cause blood vesicles to dilate
- They increase the permeability of blood vessel walls
- They act as signals that attract white blood cells to the injury site
3) Aspirins or Antihistamines
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