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Joseph Ghobrial

on 23 May 2013

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Transcript of WAY TRIPPY MAN!

- "Bicycle Day" 4/19/43 History IUPAC Name:
(6aR, 9R)- N,N- diethyl- 7-methyl- 4,6,6a,7,8,9- hexahydroindolo- [4,3-fg] quinoline- 9-carboxamide

Generic Name:
Lysergic acid Diethylamide, or Lysergsäure-diethylamid in German

In Da Streetz:
• LSD-25
 Acid, Yellow Sunshine’s, Battery Acid, Blotter, Dots, Electric Kool-Aid, Window Pane, Purple Haze, Sugar Cubes, Elvis, Blue Cheer

o LSD Combinations:
 Candy-flipping – LSD and MDMA
 Frisco Special – LSD, cocaine, and heroin
 Outer Limits – Crack and LSD
 Black Acid – LSD and PCP

o LSD Users:
 Acid freak/head, Explorer’s Club (group of LSD users)

o Other Slang
 Yen Sleep - restless, drowsy state after LSD use What do you call me? Figure 2. Molecular structure of LSD Albert Hoffman; the Swiss chemist who discovered LSD - LSD reacts with a number of receptors that inhibit serotonergic cell from firing when sparing postsynaptic serotonergic receptors from up regulation/down regulation.

- The action of 5 HT is key in understanding the function of LSD. 5-HT is produced by a small number of neurons most of which lie in the raphe nuclei (RN) of the midbrain.

- One major target of the RN is the locus coeruleus (LC), which controls the release of norepinephrine, which regulates the control of the sympathetic nervous system.

- The activation of different receptors in the serotonergic system then leads to the psychedelic effects of LSD. It is also to be noted that receptor activation by LSD is time dependent.
- Where 15 to 30 min after administration the main class of receptors being affected are the 5-HT receptors and after about 90 minutes the D2 receptors play a bigger role. How it works: Clinical Indications
One should not take LSD:
•If taking any antipsychotic or antidepressant drugs
•If taking any other hallucinogenic drugs, as it may lead to an overwhelming state of mind
•If suffering from a mental illness, as effects of LSD may exacerbate existing disorder
•If suffering from hypertension
•If previous history of tachycardia or cardiac abnormalities
•If pregnant, as LSD can cause uterine contractions and could negatively impact a pregnancy
•In combination with chemotherapeutic drugs
•Because it is illegal!! Contraindications Unwanted Effects Major:
•Long-lasting psychoses (depression and schizophrenia)
•Irreversible brain damage (constant “tripping”)
•Impaired short-term memory

•Reduced/increased appetite
•Increased heart rate and body temperature
• Acid “flashbacks”, in which parts of an acid experience are re-lived after the drug has worn off
•Hallucinations/Altered perceptions of time and reality
•Psycho-physical dissociation
- Blotter paper
- Dropped straight onto the tongue or in the eye.
- injected IV
- Powder
- Pill

Distribution within the body:
- Diffuses into all tissues of the body and crosses the
blood-brain barrier.

The effects of LSD take place gradually within 30-60 minutes after taking the drug, and reach peak within 2 to 4 hours and diminish within 10-12 hours.
LSD is metabolized in the liver.

Excretion: LSD has an elimination half life of approx 2 hrs and is excreted through urine. Pharmacokinetics
A standard dose with noticeable hallucinogenic effects is about 20-80μg. Threshold effects can be felt with as little as 20μg. Experienced users typically administer 100-200μg for a “good high”. A single LSD blotter usually contains between 30 - 100μg of LSD. A single drop of potent liquid LSD could be 50 times a normal dose. The dosage of a single square of gelatin LSD (mixing liquid LSD with gelatin and forming it into small squares) ranges between 50 and 150μg. Dosage Toxicity •It is estimated that the LD50 for LSD is in a range from 200 µg/kg to over 1mg/kg of body mass, or in general, any dose over 12,000µg
•Reports have shown that cases regarding overdose are minimal to none
•Some sources report an overdose in Kentucky in 1975 where a man was injected, via IV, with about 320mg. This is an extremely large amount of LSD to take through IV (case still controversial)
•Due to lack of recorded overdoses, sources vary regarding the estimated lethal doses for humans. Fun Facts!
• To be in possession of LSD was finally made illegal in the United Sates on October 24, 1968 in California
• LSD comes in a variety of colors and shape the evolution of how LSD came to look the way it does today is as follows:
o Was first sold in what looked like sugar cubes
o Was then changed into a tablet form
o In 1968 LSD appeared in a bright orange tablet (measured roughly 6mm across) was given the nick name “Orange Sunshine” – acid was the first form of LSD that became widely available after it was made illegal to be in possession of the drug
o Then came “computer acid” or “blotter paper LSD.” This is generally what we think of when LSD comes to mind, many colors and a variety of different designs can be made

•In the 1950s the US Central Intelligence Agency administered LSD to CIA employees, military personnel, doctors, other government agents, mentally ill patients, and members of the general public under a research program in order to study their reactions to the drug without the persons knowledge that they had ingested the drug – the code name of this operation was Project MKULTRA
•The Beatles hit song, “Lucy in the Sky with Diamonds”, is said to be about LSD by Paul McCartney himself. Blotter paper LSD – one among many blotter paper images The effects of LSD normally depend on dosage, tolerance, body weight, age, and sex. It is a potent psychotomimetic drug that causes sensory distortion and hallucination.

Some of its potential uses are:
An recreational drug as a hallucinogen
An entheogen for spiritual purposes
An agent in psychedelic therapy (therapeutic practices involving the use of psychoactive drugs):
o Treats alcoholism
o Relieves anxiety in terminal ill patients

Treats some forms of schizophrenia
Reduces cluster headache ( an immense degree of pain on only one side of the head)
An analgesic for serious and chronic pain caused by cancer or other major trauma
Other uses in psychotherapy:
o Personality disorder
Transient situational personality disorder
o Psychoneurotic disorder (mental disorder that causes deficit in functioning) Works Cited Abbas A.I.,et al. (November 2009). "Predicting new molecular
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<http://psychede.tripod.com/> http://andreaswittmann1.blogspot.com/2012/02/albert-and-me.html - Main intention was to be used to obtain a respiratory and circulatory stimulant (analeptic)

- after "Bicycle Day" Hofman thought it to be a great psych drug. http://www.guardian.co.uk/science/2008/apr/30/drugs.chemistry http://people.tribe.net/5f4ed4e3-5894-489b-b08a-e1ab97de3788/photos/4dc422ef-44a8-4387-8094-1ec32634beba http://earlcapps.blogspot.com/2012/03/someones-doing-lsd.html http://azarius.net/news/482/Revisiting_LSD_as_a_treatment_for_alcoholism/ http://www.tagohio.com/lsd.htm Blotter paper http://www.tumblr.com/tagged/liquid%20lsd
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