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Host-Pathogen Interactions: Toxoplasma gondii

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by

Marie Sim

on 16 August 2013

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Transcript of Host-Pathogen Interactions: Toxoplasma gondii

Host-Pathogen Interactions: Toxoplasma gondii

Epigenetics in Toxoplasma gondii
Parasites found to possess epigenetic enzymes: histone modification and chromatin remodelling
Stage conversion associated with change in mRNA content
Bradyzoite-specific promoters are:
- hypoacelated in tachyzoites
- acetylated in differentiation conditions
Might epigenetically modify the host's cells genome
and disrupt normal gene expression =
results in disease manifestations
Methods - Bioinformatics
Questions?
Thank you!
Marie Sim
Honours Student
Genetics and Health
Supervisors:
Dr Sarra Jamieson
W/Prof Jenefer Blackwell

ubiquitous, obligate intracellular protozoan parasite of warm-blooded animals
third most common cause of food-borne deaths
congenital transmission occurs 1 = 1000 births in USA
What is toxoplasma gondii?
Symptoms
Congenital toxoplasmosis:
intracranial calcification
hydrocephalus
chorioretinitis
Life cycle of T. gondii
Toxoplasmosis in immunocompetent individuals:
lymphadenopathy
fever
fatigue and malaise
Acute toxoplasmosis:
meningoencephalitis
Epidemiology
Approximately 85% of women of childbearing age susceptible to acute infection with Toxoplasma
Economic burden of Toxoplasma infection estimated to be $7.7 billion per year (primarily CT)
Major cause of mortality in AIDS patients in undeveloped countries
Toxoplasmosis linked to development of schizophrenia
Methods - Time-point infection experiment
Future works
Microfluidic Array Analysis
Acknowledgements
Aims of the project
Analysis of gene expression and DNA methylation between infected and non-infected cells
Replication analysis in a novel brain cell line for further investigation
Acknowledgements
Acknowledgements
T. gondii
Belongs to the phlyum Apicomplexa
Takes several forms such as:

- Sporozoites
shed in cat faeces
- Tachyzoites
multiply rapidly
infect any nucleated cell
- Bradyzoites

multiply slowly
persist in tissue cysts
Full transcript