Send the link below via email or IMCopy
Present to your audienceStart remote presentation
- Invited audience members will follow you as you navigate and present
- People invited to a presentation do not need a Prezi account
- This link expires 10 minutes after you close the presentation
- A maximum of 30 users can follow your presentation
- Learn more about this feature in our knowledge base article
Do you really want to delete this prezi?
Neither you, nor the coeditors you shared it with will be able to recover it again.
Make your likes visible on Facebook?
Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.
Host-Pathogen Interactions: Toxoplasma gondii
Transcript of Host-Pathogen Interactions: Toxoplasma gondii
Epigenetics in Toxoplasma gondii
Parasites found to possess epigenetic enzymes: histone modification and chromatin remodelling
Stage conversion associated with change in mRNA content
Bradyzoite-specific promoters are:
- hypoacelated in tachyzoites
- acetylated in differentiation conditions
Might epigenetically modify the host's cells genome
and disrupt normal gene expression =
results in disease manifestations
Methods - Bioinformatics
Genetics and Health
Dr Sarra Jamieson
W/Prof Jenefer Blackwell
ubiquitous, obligate intracellular protozoan parasite of warm-blooded animals
third most common cause of food-borne deaths
congenital transmission occurs 1 = 1000 births in USA
What is toxoplasma gondii?
Life cycle of T. gondii
Toxoplasmosis in immunocompetent individuals:
fatigue and malaise
Approximately 85% of women of childbearing age susceptible to acute infection with Toxoplasma
Economic burden of Toxoplasma infection estimated to be $7.7 billion per year (primarily CT)
Major cause of mortality in AIDS patients in undeveloped countries
Toxoplasmosis linked to development of schizophrenia
Methods - Time-point infection experiment
Microfluidic Array Analysis
Aims of the project
Analysis of gene expression and DNA methylation between infected and non-infected cells
Replication analysis in a novel brain cell line for further investigation
Belongs to the phlyum Apicomplexa
Takes several forms such as:
shed in cat faeces
infect any nucleated cell
persist in tissue cysts