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Transcript of Dengue Fever
National Notifiable Disease List (NNDL)
Confirmed/Probable cases Prevention and Control Epidemiology Epidemiology of Dengue Fever Types of Dengue
Immunopathophysiology Transmission Cycle Virology Virology Scitable by nature EDUCTION; http://www.nature.com/scitable/topicpage/dengue-viruses-22400925 Scitable by nature EDUCTION; http://www.nature.com/scitable/topicpage/dengue-viruses-22400925 Aedes aegypti mosquito Bioinformatics Resource for Invertebrate Vectors of Human Pathogens, https://www.vectorbase.org/organisms/aedes-aegypti/liverpool-lvp Vectors McBride WJH, Bielefeldt-Ohmann H. Microbes and Infection. 2000 7;2(9):1041-50. Gao, Huajian. PNAS July 5, 2005 102;27: 9469–9474 http://www.pnas.org/content/102/27/9469/F1.expansion.html Pathogenesis
Immunopathophysiology Dengue Fever Classic Dengue Fever Dengue Haemorrhagic Fever Flu like symptoms
Cleared by immune system with supportive therapy More severe
Can be fatal
Dengue Shock Syndrome Targets symptomatic relief.
Facilitate immune system to clear the infection.
Analgesics and NSAIDs
Supportive fluids if patient doesn’t feel like drinking.
Patients with classic DF symptoms should be closely monitored - risk of DHF. Treatment and management of Classic Dengue Treatment for DHF aims to prevent the patient encountering Dengue Shock Syndrome (DSS)
Treatment for DHF is determined on a case by case basis, but targets the control of the acute symptoms associated with DHF Treatment and management of DHF Dengue: Guidelines for diagnosis, treatment and prevention, pg 100 Dengue: Guidelines for diagnosis, treatment and prevention, pg 102 Diagnostic Tests:
Haemagglutination Inhibition Test
Serology Full Blood Count (FBE)
White Cell Count (WCC)
Liver Function Tests (LFTs) Monitoring Public Health Regulation 2005 (Queensland)
Public Health Act 2005 (Queensland)
Public Health and Wellbeing Regulations 2009 (Victoria) Legislations- Prevention And Control http://www.dengue.gov.sg/images/sites/unusual_breeding_grounds.jpg http://www.virtualmedicalcentre.com/health-investigation/pcr-polymerase-chain-reaction/60 Summary table detailing clinical features and lab results at each stage of Dengue Fever
Practice Guidelines on Management of Dengue Infection in Adults. – 2010 Ministry of Health, Malaysia http://pccstem.org/wp-content/uploads/2013/01/My-Excited-Face.jpg http://media.tumblr.com/tumblr_ls76d2R6KC1qj4v18.jpg Dengue Shock Syndrome Dengue Infection Leucopaenia Thrombocytopaenia Dengue Haemorrhagic Fever Rising HCT Thrombocytopaenia WHO 2012, countries or areas at risk, http://apps.who.int/ithmap/ Haemagglutination Inhibition Test Dengue: Guidelines for diagnosis, treatment and prevention, pg 100 MAC-ELISA RT-PCR Confirmed case Clinical Evidence Laboratory Definitive Evidence Probable Case Epidemiological Evidence
(Travel to area with known dengue activity) Laboratory Suggestive Evidence Clinical Evidence Vector Control Methods Insecticides "Lure and Kill" Ovitraps Removal of breeding containers Prevention Dengue disease information (signs and symptoms) Mosquito breeding sites Use of bed-nets Times of more prevalence Traveller's Dengue Use of repellants Education Disease surveillance
Environmental/Social surveillance Vector Control: Diagnostics: Control Surveillance: Chemicals (pesticides)
Mosquito inspection programs Early detection PUBLIC HEALTH MEASURES Live Attenuated Viruses Chimeric Live Attenuated Viruses Nucleic-Acid Based Inactivated/Sub-unit Dengue Vaccinations Tourist guy, A Current Affair, http://www.youtube.co/watch?v=InsNuc0do7Q Dengue prevalence Australia, MJA, https://www.mja.com.au/journal/2009/190/5/dengue-and-climate-change-australia-predictions-future-should-incorporate Notifications Dengue Australia, http://www.denguematters.info/content/issue-6-dengue-fever-rise Distribution of Dengue Serotypes, nature.com, http://www.nature.com/scitable/content/the-change-in-distribution-of-dengue-serotypes-22401317 http://www.cdc.gov/dengue/images/DengueInfection.jpg Vaccines