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Transcript of Glomerular Disease
Hypertension-sudden or insidious onset
Edema (plasma moves into interstitial space secondary to hypoalbuminemia)
Decrease in GFR (Glomerular Filtration Rate)
Elevated plasma creatinine & urea
Reduced creatinine clearance
Proteinuria Inc. Glom permeability & dec resorption leads to edema also. Excretion of protein 3.5g or more in urine/day.
More common in children than adults
Basement membrane and podocyte injury
Loss of protein and negative electrical charge.
Hypoalbuminemia results from urinary losses of protein Primary glomerular injury: immunologic responses, ischemia, free radicals, drugs, toxins, vascular disorders and infection i.e. URI in Berger's Disease.
Secondary: systemic diseases i.e. DM, Lupus, CHF, HIV related kidney disease. Nephrotic syndrome Clinical Manifestations EDEMA
Vitamin D deficiency
Contributes to bone loss & infection Diagnosis and Treatment
24hour urine collection
Normal protein, low fat, salt restricted diet
Nephrotic vs. Nephritic syndromes Nephrotic syndrome urine is characterized by severe loss of protein (proteinuria) 3.5 g or more/day
Nephritic syndrome urine is characterized by:
Red blood cells &
Proteinuria (not severe)