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Glomerular Disease

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Ruth Mawyer

on 11 March 2013

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Transcript of Glomerular Disease

Glomerular Disorders Glomerulonephritis Nephrotic Syndrome The end of Glomerular Disease Inflammation of the glomerulus caused by primary or secondary glomerular injury. Glomerular Disease Clin. Manifestations and Labs
Hypertension-sudden or insidious onset
Edema (plasma moves into interstitial space secondary to hypoalbuminemia)
Elevated BUN
Decrease in GFR (Glomerular Filtration Rate)
Elevated plasma creatinine & urea
Reduced creatinine clearance
Proteinuria Inc. Glom permeability & dec resorption leads to edema also. Excretion of protein 3.5g or more in urine/day.
More common in children than adults

Basement membrane and podocyte injury
increased permeability
Loss of protein and negative electrical charge.
Hypoalbuminemia results from urinary losses of protein Primary glomerular injury: immunologic responses, ischemia, free radicals, drugs, toxins, vascular disorders and infection i.e. URI in Berger's Disease.
Secondary: systemic diseases i.e. DM, Lupus, CHF, HIV related kidney disease. Nephrotic syndrome Clinical Manifestations EDEMA
Vitamin D deficiency
Contributes to bone loss & infection Diagnosis and Treatment
24hour urine collection
Normal protein, low fat, salt restricted diet
immunnosuppressive drugs
Nephrotic vs. Nephritic syndromes Nephrotic syndrome urine is characterized by severe loss of protein (proteinuria) 3.5 g or more/day
Nephritic syndrome urine is characterized by:
Red blood cells &
Proteinuria (not severe)
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