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PEOPLE Program 2012 BME 201

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Anazoila Contreras

on 15 April 2014

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Transcript of PEOPLE Program 2012 BME 201

Alginate Gel
&
Bioreactor
What is BME?
The PEOPLE Program 2012 BME 201 Internship
The World of BME
By:
Anazoila Contreras
Christian A. Real Merino
David Ross III
Anthony Diaz
Intro to the Design Project
Problem Statement
Intro to Alginate/Biomaterial
Description of design
Methods of testing
Results
Conclusion
Q. & A.
BME
=
Biomedical Engineering
The use of engineering principles and design concepts of medicine and biology.
There are 5 Fields,
some include:
Medical Instrumentation
Medical Imaging
Biomechanics
Biomaterials/
Tissue Engineering
Health Care Systems
Electrical Circuits
Bread Board
Measure what we want
Idea of the Product
Gel
Diameter = 15 mm
Height = 1 cm
Volume = 2 mL
Force sensing resistor
Breaking of gel
Make FSR
How gel was compressing
Measures how much force the gel can take before breaking
Measure of acidity in the gel
Compatibility with the human body
Human acidity = 7.4

Sample 1:
Sample 2:
Sample 3:
Sample 4:
Sample 5:
Sample 6:
Average:
Young's Modulus
35832 Pa
1929 Pa
58252 Pa
12559 Pa
8813.5 Pa
23603 Pa
23498.08333 Pa
Ultimate Strength
14593.91 Pa
10567.13 Pa
18416.06 Pa
6939.49 Pa
4769.48 Pa
8894.78 Pa
10696.80833 Pa
Pa=Pascals
Alginate gel is a biomaterial
Drug deliver
Compatible with the human body
Better understanding of alginate gel
Visual image
Use the fundamentals of BME
(Alginate Gels)
Methods of Testing
A  microcontroller is a small computer on a single integrated circuit containing a processor core, memory, and programmable input/output peripherals.
Microcontroller & Power Support
 Force sensing resistors, or FSRs, are robust polymer thick film (PTF) devices that exhibit a decrease in resistance with increase in force applied to the surface of the sensor.
FSR
MTS
A pH meter is an electronic instrument used for measuring the pH (acidity or alkalinity) of a liquid (though special probes are sometimes used to measure the pH of semi-solid substances).
A typical pH meter consists of a special measuring probe (a glass electrode) connected to an electronic meter that measures and displays the pH reading.
pH Meter
LabVIEW (short for Laboratory Virtual Instrumentation Engineering Workbench).
LabVIEW is commonly used for data acquisition, instrument control, and  industrial automation on a variety of platforms including Microsoft Windows, various versions of UNIX, Linux, and Mac OS X.
LabVIEW
Gel = 23498.08333 Pascals
Lead: 13789.5145800 Pascals
Skeletal muscle: 12000 Pascals
Breast tumor: 4000 Pascals
Kidney Swine : 2500 Pascals
Gels failure
Change chelating time
Amount of materials used
Change environment
Questions?
Alginate/Biomaterial
Compatible to the body.
Super absorbent natural of synthetic polymers (containing over 99% water).
Process degree of flexibility similar to natural tissues.
Ability to sense changes of pH and temperature.
Provides the absorption,desloughing & debriding capacities of necrotics & fibrotic tissues.
About Alginate Gels
Contact Lenses
Replacement Heart Valves
Hygrogels/Alginate Gels
Dental Crowns
Breast Implants
Any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, or replaces a natural function.
What are Biomaterials
Types of Alginate Gels
Natural material derived from algae which consists of polysaccharides (sugar molecules)
Composed of repeating blocks of D-mannuronic acid & L-guluronic acid residues.
What are Alginate Gels?
MTS (Mechanical Testing System).
An apparatus in which the plunger applies force to test the young's modulus.
References:

1. Gemeinhart, R. A., Guo, C., Fast Swelling Hydrogel Systems. 2004. 245-257.
2. BME 511 Lab #1. 2011.
3. Fisher Scientific. BP6651, 2012
4. Neiser S., Draget K.I., Smidrod O. “Interactions in bovine serum albumin-calcium alginate gel systems”. 1999. Food Hydrocolloids. 13: 445-458.
5. Dainty A., Goulding K., Robinson P., Sinpkins I., Trevan M. “Stability of Alginate-Immobilized Algal Cells”. 1985. Biotechnology and Bioengineering. XXVII:210-216.
6. Kuo C., Ma P. “Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Par 1. Structure, gelation rate and mechanical properties”. 2001. Biomaterials. 22: 511-521
7. Rutala W and Weber D. “Draft Guideline for Disinfection and Sterilization in Healthcare Facilities”. 2002. CDC.
8. Mendes G., Brandao T., Silva C. “Ethylene oxide sterilization of medical devices: A review” 2007. American J. of Infection Control. 35(9):574-581
9. Skalak R, Fox CF, eds., Tissue Engineering (New York: Alan R. Liss, Inc., 1988).
10. UW-Madison BME 511 Lab #1 Introduction to the Tissue Culture Lab. 2011.
11. UW- Madison BME 511 Lab #4 Alginate Encapsulation Technique. 2011.
12. Wan L, Arnold D., Guo E., Lu H., and Mow V. “Calcium concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs”. Cell Mol Bioeng. 2008 March 1; 1(1): 93–102.
13. Drury J., Dennis R., Mooney D., “The tensile properties of alginate hydrogels”. Biomaterials 2004. 25:3187–3199
14. Boontheekul T., Kong H., Mooney D. “Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution” Biomaterials. 2005. 26(15):2455-2465
15. Kuo C., Ma P. “Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Par 1. Structure, gelation rate and mechanical properties”. Biomaterials. 2001. 22: 511-521
16. "BME 462: Medical Instrumentation." Home, College of Engineering @ The University of Wisconsin-Madison, initiatives in energy, health, nanotechnology, security, and information technology. N.p., n.d. Web. 27 July 2012. <http://www.engr.wisc.edu/bme/courses/bme462.html>.
17. "Biomechanics - Wikipedia, the free encyclopedia." Wikipedia, the free encyclopedia. N.p., n.d. Web. 27 July 2012. <http://en.wikipedia.org/wiki/Biomechanics>.
18. "Medical imaging - Wikipedia, the free encyclopedia." Wikipedia, the free encyclopedia. N.p., n.d. Web. 27 July 2012. <http://en.wikipedia.org/wiki/Medical_imaging>.
19."Tissue engineering - Wikipedia, the free encyclopedia." Wikipedia, the free encyclopedia. N.p., n.d. Web. 27 July 2012. <http://en.wikipedia.org/wiki/Tissue_engineering>.
20. "Health system - Wikipedia, the free encyclopedia." Wikipedia, the free encyclopedia. N.p., n.d. Web. 27 July 2012. <http://en.wikipedia.org/wiki/Health_system>.
Bread Board
LabView
pH Meter
SolidWorks
FSR = Force Sensing Resistor
FSR Making
FSR & Bread Board
Caliper
MTS = Mechanical Testing System
Young's Modulus Graph
Gustavo Zach Vargas
Brad Lindevig
Team Work
Josh Zent
Mechanical Testing System
(MTS)
Micropipettes
Alginate Gels
Microncontroller
Circuit with op-amp
Measuring out CaCO to make our PBS formula.
3
Alginate Gels
Adding PBS to keep the Alginate gels hydrated
FSR
LabView Circuit
Christian entering data
Plastic container holding Alginate gels
Ana testing the alginate gel
pH meter
Force Compresser
Circuit board connected to the microcontroller
Our Intructers...
Biomedical Engineering Internship
Full transcript