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Biology Chemistry Metabolism pathway

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Zhiwei Dong

on 29 June 2011

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Transcript of Biology Chemistry Metabolism pathway

Biochemistry Metabolism Pathways Glycolysis Glucose Glucose 6-phosphate Fructose 6-phosphate Fructose 1,6-biphosphate glyceraldehyde 3-phosphate Dihydroxyacetone phosphate glyceraldehyde 3-phosphate 1,3-Biphosphoglycerate (2) 3-Phosphoglycerate (2) 2-Phosphoglycerate (2) Phosphoenolpyruvate (2) Pyruvate (2) Hexokinase phosphoglucose isomerase Phosphofructokinase 1 Aldolase Triose Phosphate isomerase Glyceraldehyde 3-phosphate dehydrogenase The phosphoglycerate kinase The phosphoglycerate mutase Enolase The pyruvate
kinase Glucose
6-phosphatase Fructose 1,6-biphosphatase Pyruvate carboxylase Glyconeogenesis Acetyl-CoA (2) Lactate (2) Ethanol (2) Blood glucose Glycogen Lactate Blood lactate Glucose Cori Cycle Liver Muscle Pyruvate Oxaloacetate PEP Malate Malate Oxaloacetate Citrate Isocitrate a-ketoglutarate Succinyl-CoA Succinate Fumarate L-malate Oxaloacetate Citrate Cycle Citrate
synthase Anconitase Isocitrate
dehydrogenase a-ketoglutarate
dehydrogenase complex Succinyl-CoA
synthetase Succinate
dehydrogenase Fumarase Malate
dehydrogenase Glutamate Pro,His,Gln,Arg Ile,,Met,,Ser,,Thr,,Val Phe,,Tyr Asn,,Asp Ala, Cys, Gly, Ser, Thr, Trp Acetoacetyl-CoA Ketone bodies Leu,Lys
Phe,Trp,Tyr Ile,Leu
Thr,Tyr Pyruvate Pyruvate Glucose 1-phosphate UDP-glucose Glycogen Nonreducing end
of glycogen chain UDP-glucose pyrophosphrylase Glycogen
synthase Glycogen
phosphorylase Glycogenesis & Glycogenolysis 6-Phosphogluconate Ribulose 5-phospate Ribose 5-phosphate Pentose phosphate pathway Glyoxylate Malate Oxaloacetate Glyoxylate
Cycle (not in vertebrates) Fatty acid Fatty acyl-CoA Carnitine CoA-SH Fatty acyl
carnitine Fatty acyl
carnitine Carnitine CoA-SH Fatty acyl-CoA Outer membrane Inter membrane Inter membrane
space Cartinine
acyltransferase I Cartinine
acyltransferase II Enoyl-CoA b-hydroxylacyl-CoA Ketoacyl-CoA Fatty
acyl-CoA -1 Fatty acyl-CoA synthetase HMG-CoA Acetoacetate Acetone b-hydroxyl
butyrate Fatty acyl-CoA
dehydrogenase Enoyl-CoA
dehydratase b-hydroxylacyl-CoA
dehydogenase Thiolase Thiolase Pyruvate TCA,TCP Acetyl-ACP Malonyl-ACP Acetyl group Malonyl group ACP KS b-ketobutyryl-ACP D-b-hydroxybutyryl-ACP KR Trans-2-butenoyl-ACP HD Butenoyl-ACP ER AT,MT Repeating four-step
reaction sequence
many times The synthesis of
fatty acids Fatty acid oxidation Mitochondria Muscle protein Amino acid NH Glutmate Pyruvate Alanine a-ketoglutarate Blood alanine Alanine Pyruvate a-ketoglutarate Glutmate NH Alanine-glucose
Cycle Alanine aminotransferase Alanine aminotransferase Urea Urea Cycle NH Carbamoyl
phosphate Ornithine Citrulline Pi Bicarbonate, 2ATP Ornithine Citrulline Arginine Arginino-succinate Urea Fumarate L-malate Oxaloacetate Asparate Asparate Glutamate a-ketoglutarate Carbamoyl phosphate
synthetase I Ornithine
transcarbamoylase Argininosuccinate
synthase Argininosuccinate
lyase Arginase Urea Cycle Mitochondria Glutamate Pro,Gln,Arg Ser Ala, Val, Leu
Lys, Ile Asp, Asn, Thr, Met
Lys, Ile Gly, Cys Try, Phe, Tyr His 4 + 4 + + 4 16110901
20092283 董之威 Glucose 6-phosphate
ehydrogenase Pyruvate
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