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Transcript of Biobots
UIUC Biomedical Engineering Society
What is a Biobot?
How is it made?
Electrical fabrication of Biobots
What is it used for?
Bio-Bots are miniature (less than 1cm long), walking robots powered by muscle cells and controlled by light or electrical pulses
The use of these soft robots may impact the ability to design machines and systems that can respond to complex environmental signals - giving control over their function by channeling their biological abilities.
They are composed of
a living cell scaffold stretched around the legs of a
flexible 3-D printed hydrogel body
The design was influenced by the muscle-tendon-bone complex found naturally in animals.
Utilizing muscle cells and an electrical pulse as a trigger, researchers could control the bio-bots and leaves the field open for building customized bots for specific applications.
Skeleton is designed using computer software (CAD) such as Solidworks or Autodesk with 3D printing. Leg’s are designed with different heights to direct locomotion.
The bot skeleton is printed using a technique called stereolithography that uses fluid that hardens (photopolymerizes) when exposed to light.
For collagen muscle strips, an ice-cold cell–matrix solution of Matrigel, fibrinogen, thrombin, and muscle myoblasts (C2C12s) are added to 3D-printed ring molds.
Fun fact: your body uses fibrinogen and thrombin to clot/stop blood after a cut!
The cells are mutated to express channel-proteins that are activated by light which allows the muscle ring to contract. The cells were designed to create a red fluorescent protein that lets them to be seen (right).
Drug delivery and cancer treatments
It can recognize a certain chemical signal in the body, move towards it, and release its chemical payload.
Delivering a neutralizing agent to an area of the body where specific toxin levels are high
Ferrying a drug that is being used in chemotherapy to areas containing cancer cells.
Recognize and respond to pollutants and toxins in our environment (used as mobile environmental analyzers)
Placed in a body of water in which detergents or disinfectant by products are high and produce compounds to alleviate these issues.
What are we doing today?