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Transcript of Network
validation and analysis
Prediction of protein-protein interactions
Domain Domain interaction [DDI]
and gene clusters
pairwise data generation
To Identify Potential
Drug Targets by constructing
One drug-One target
Identifying Multiple Drug Targets (Using Network Biology)
Construction of Protein-Protein
Interaction (PPI) Networks
Analyzing network structure & properties
Examining the position of known drug targets
experimental PPIs in PA
Proteome Analyst Specialized
Subcellular Localization (PASSL)
Functional Genomics & Network Biology of Pathogenic Microbes
Pairwise compilation of ESS, FUN, TRH, OPR,LOC, PAT using Perl Scripts: Output
Trans-membrane helices [TRH]
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Tendency of a graph to be divided into clusters.
Biological Networks have high
Subset of vertices in a network such that every two proteins are connected by an edge.
Identification of groups of consistently co-expressed genes.
Sparse graph vs. Dense Graph
Number of Connections per node set
Biological networks are sparsely connected
Vipul S kumar
Shows whether a network has star-like topology or not.
Centralization approximately equal to one shows higher chances of star like topology.
Future work plan