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What do Autism and Epilepsy have in common?

National Autistic Society 2013 Conference

Deb Pal

on 2 March 2013

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Transcript of What do Autism and Epilepsy have in common?

Deb K Pal PhD MRCP
Professor of Clinical Neuroscience, King's College London What do
epilepsy and autism
have in common? conclusions more often
than chance epilepsy autism in the population autism in epilepsy epilepsy in autism CLINICAL EPIDEMIOLOGY ssri ritalin melatonin valproate topiramate cognition behaviour sleep mood appetite seizures TREATMENT comorbidities aims sleep communication repetitive
behaviours social interaction shared aetiology and mechanisms mood aggressive
behaviour adhd seizures sleep mtor-i attention training ABI mood aggressive
behaviour adhd seizures steroids hygiene
melatonin bhv mod
ritalin aeds counslng
ssris bhv mod
risperidone Abnormal excitability in
the developing brain Epilepsy and
Epileptogenesis Intellectual Disability
Behavioural Problems Disrupted
Plasticity mTOR MeCP2 FMRP Gene mutations Gene dosage TS: mTOR
Rett: MeCP2
Cell adhesion
proteins Timeline of human brain development Cellular basis of learning 20% 10 year remission Autism + Epilepsy comorbidities very similar Symptom modulation
vs Disease modification Genetic variations abnormal brain development
altered synaptic plasticity Core symptoms
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