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Polycystic Ovary Syndrome

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kayleigh todd

on 4 November 2013

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Transcript of Polycystic Ovary Syndrome

1. Define Polycystic Ovary Syndrome (PCOS)
2. Determine criteria for PCOS diagnosis
3. Examine pathophysiology and potential causes of PCOS
4. Summarize complications of PCOS
5. Identify adolescent concerns with PCOS
6. Analyze treatment options for PCOS

Polycystic Ovary Syndrome
Presented by: Kayleigh Todd & Elizabeth Conde
(Birchwood, 2013)
Define Polycystic Ovary Syndrome
"Polycystic ovary syndrome is a condition in which a woman has an imbalance of a female sex hormones. This may lead to menstrual cycle changes, cysts in the ovaries, trouble getting pregnant, and other health changes." (Medline Plus, 2013)
(InLife, 2013)
Symptoms of PCOS
• Irregular menstrual periods
• Infertility
• Obesity
• Hirsutism
• Severe acne or acne that occurs after adolescence
• Oily skin
• Acanthosis nigricans
• Multiple small cysts on the ovaries

Differential Diagnoses
(Sheehan, 2004)
(American College of Obstetricians and Gynecologists, 2011)
Diagnostic Criteria
Symptoms of PCOS
start at 2:25
Potential Causes of PCOS
Cause of PCOS is largely unknown:
-genetic factor
-controversy over whether defect is central or ovarian
-obesity is seen to increase severity of symptoms

(Franks, 2008)
Normal Ovulation
(Encyclopedia Brittanica, 2013)
Pathophysiology of PCOS
Item of Note
Adolescent Concerns
emotional support
difficult diagnosis
inconsistent treatment
lack of understanding
useful for subset of PCOS pts
addresses hyperinsulinemia
pregnancy monitoring
Ovarian Drilling
Hormone Therapy
protect against endometrial cancer
help decrease hyperandrogenic symptoms
protect against pregnancy in the event of ovulation
regulate menstrual cycle
reduce production of androgens
can be used in conjunction with anti-androgenics
menstrual irregularity
Lifestyle Modifications
Auble, B., Elder, D., Gross, A., & Hillman, J. (2013). Differences in the Management of Adolescents with Polycystic Ovary Syndrome across Pediatric Specialties. Journal of Pediatric Adolescent Gynecology , 26, 234-238.

Frank, S. (2008, May). Polycystic ovary syndrome in adolescents . International Journal of Obesity , 1035-1041.

Hoeger, K., Davidson, K., Kochman, L., & Cherry, T. (2008). The Impact of Metformin, Oral Contraceptives, and Lifestyle Modification on Polycystic Ovary Syndrome in Obese Adolescent Women in Two Randomized, Placebo- Controlled Clinical Trials. Journal of Clinical Endocrine Medicine , 93 (11), 4299-4306.

Hunter, M.H., Sterrett, J. J. (2000). Polycystic ovary syndrome: It's not just infertility. American Family Physician, 62(5), 1079-1088.

Kliegman, R., & Behrman, R. (2007). Nelson textbook of pediatrics. (18th ed.). Philidelphia,
PA: Saunders.

Mathur, R., Alexander, C.J., Yano, J., Trivax, B., Azziz, R. (2008). Use of metformin in polycystic ovary syndrome. American Journal of Obstetric Gynecology, 199(6), 596-609. doi: 10.1016/j.ajog.2008.09.010.

M. Hickey, D. M. (2009). The Relationship between Maternal and Umbilical Cord Androgen Levels and Polycystic Ovary Syndrome in Adolescence: A Prospective Cohort Study. Journal of Clinical Endocrine Medicine , 94 (10), 3714-3720.

McCance, K., Heuther, S., Brashers, V., & Rote, N. (2010). Pathophysiology: The Biologic Basis for Disease in Adults and Children. Maryland Heights, MO: Mosby.
Moran, L. J., Misso, M., Wild, R. A., & Nor, R. (2010). Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction Update , 16 (4), 347-363.

Patient Information: Polycystic Ovary Syndrome (PCOS) (Beyond the Basics). (2012, July, 24). Up to Date. Retrieved November 1, 2013, from http://www.uptodate.com/contents/polycystic-ovary-syndrome-pcos-beyond-the-basics

Polycystic Ovary Syndrome (PCOS): For Researchers and Health Care Providers. (n.d.). National Institute of Health. Retrieved October 21, 2013, from

Polycystic Ovary Syndrome: MedlinePlus. (2013, September 30). Medline Plus. Retrieved October 21, 2013, from

Roe, A. H., Dokras, A. (2011). The diagnosis of polycystic ovary syndrome in adolescents. Reviews in Obstetric Gynecology, 4(2), 45–51.

Rossi, B., Sukalich, S., Droz, J., & Griffin, A. (2008). Prevalence of Metabolic Syndrome and Related Characteristics in Obese Adolescents with and without Polycystic Ovary Syndrome. Journal of Clinical Endocrine Medicine , 93 (12), 4780-4786.

Sheehan, M. T. (2004). Polycystic Ovarian Syndrome: Diagnosis and Management. Clinical Medicine and Research, 2(1), 13–27.

Stein-Leventhal syndrome (medical disorder) -- Encyclopedia Britannica. (n.d.). Retrieved November 1, 2013, from http://www.britannica.com/EBchecked/topic/564970/Stein- Leventhal-syndrome

Trent, M.E., Rich, M., Austin, S.B., & Gordon, C.M. (2003). Fertility concerns and sexual behavior in adolescent girls with polycystic ovary syndrome: implications for quality of life. Journal of Pediatric Adolescent Gynecology, 16(1), 33-37.

Vilmann, L., Thisted, E., Baker, J., & Holm, J.-C. (2012). Development of Obesity and Polycystic Ovary Syndrome in Adolescents. Hormone Research in Pediatrics , 78, 269–278 .

Williams, R., Ong, K., & Dunger, D. (2013). Polycystic ovarian syndrome during puberty and adolescence . Molecular and Cellular Endocrinology , 373, 61-67.

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