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Alice in Wonderland Syndrome

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Zoe R

on 26 May 2015

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Transcript of Alice in Wonderland Syndrome

Disorienting neurological condition that affects human perception.
What is AIWS?
AIWS Simulation
Brief History
First described by Dr. John Todd, a psychiatrist who studied patients with severe migraines in 1955
Lewis Carroll is believed to have suffered from these hallucinations
Influenced the writing of his famous novel
Alice's Adventures in Wonderland
By Ella, Kate, and Zoe
Alice in Wonderland Syndrome
Epstein-Barr Virus
Some cases experienced few symptoms of EBV, but several of AIWS
Several reported cases of patients who had mono developed AIWS after
People with AIWS
Temporal Lobe Epilepsy
Affects 37 million Americans today
Most commonly affects women
Caused by very low Serotonin levels
During a migraine the metabolic rate of 5-HTP decreases
Major Symptoms:
Seeing objects as different sizes and colors than they actually are
Distorted perceptions of one's own body
Possible Causes:
Epstein-Barr Virus (mononucleosis)
Migraine headaches
Temporal Lobe Epilepsy
Temporal lobe: processes vision, emotions, memories
Effects mainly girls of ages 3-12
50% of patients with epilepsy have TLE
Lack of Serotonin Causes:
Disruption in sleep patterns
Inability to manage pain
Seizures cause auras, which have symptoms:
Olfactory, auditory, and gustatory illusions
Distortions of shape, size, color, and distance of objects
AIWS suffers very commonly experience migraines directly before an episode
"Lilliputian" hallucinations: micropsia and macropsia
Teliopsia and peliopsia
"Quite suddenly objects appear small and distant or large and close . I feel as I am getting shorter and smaller 'shrinking' and also the size of persons are not longer than my index finger. Sometimes I see the blind in the window or the television getting up and down, or my leg or arm is swinging. I may hear the voices of people quite loud and close or faint and far. Occasionally, I experience attacks of migrainous headache associated with eye redness, flashes of lights and a feeling of giddiness."
- 17 year old male with AIWS
"Have I gone mad? I'm afraid so, but let me tell you something, the best people usually are."
- Lewis Carroll, Alice in Wonderland
Neurotransmitters: GABA, glutamate, serotonin
Episodes may occur from glia brain cells' changes in ability to regular glutamate
Lack of serotonin in areas where seizures start
Temporal Lobe Epilepsy
Vagus nerve stimulation
Anteromedial temporal resection
Anti-epileptic drugs
No cure, but many pain management treatments exist
Pain Relieving Medication
Preventative Medication
Epstein-Barr Virus
No specific treatment
Staying hydrated, getting rest, and taking pain and fever medications.
No vaccine but some prevention methods
Temporal illusions
Dissociative experiences
Illusions and hallucinations
Spread through bodily fluids.
Common symptoms:
Fever and fatigue
Rash inflamed throat, body rashes
Swollen lymph nodes
Causes illnesses such as infectious mononucleosis.
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