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Transcript of Alzheimers
Sporadic vs Familial
Amyloid Precursor Protein (APP)
Beta Amyloid (Aβ) peptides
In vivo models
In vitro models
Non invasive tissue sampling
Difficult to stimulate ageing
Disrupts the interconnected nature between various cell types found in the brain
The Future of iPSC?
Non-neuronal cell involvement
When degeneration = pathology
When degeneration is conducive to drugs
Universality of drugs
What is Ageing?
Why do we Age?
IGF Signaling Pathway
Relationship between IGF, Insulin and AD
Morris Water Maze
AAP23 Mice Model
ROS & ApoE
WE CAN'T STOP AGEING!
Neurotrophins and Growth Factors
Physical Activity and APP
Improved water maze performance
Who is susceptible?
High blood pressure
Physical activity and Tau
Phenotypes manifest in months not years
Isolated pathological components
Learning and memory impairement
Aberrant network connections
Genes involved in sporadic AD
Are there good experimental models for Alzheimer's Disease
Alzheimer's is multifactorial
No cure available yet
Multiple therapeutic targets developed
Ageing is inevitable