Send the link below via email or IMCopy
Present to your audienceStart remote presentation
- Invited audience members will follow you as you navigate and present
- People invited to a presentation do not need a Prezi account
- This link expires 10 minutes after you close the presentation
- A maximum of 30 users can follow your presentation
- Learn more about this feature in our knowledge base article
Do you really want to delete this prezi?
Neither you, nor the coeditors you shared it with will be able to recover it again.
Make your likes visible on Facebook?
Connect your Facebook account to Prezi and let your likes appear on your timeline.
You can change this under Settings & Account at any time.
Connective Tissue Disease
Transcript of Connective Tissue Disease
Share certain common features Inflammation of skin, joints and other structures rich in connective tissue
Altered patterns of immunoregulation Production of autoantibodies
Abnormalities of cell-mediated immunity Systemic Lupus
Erythematosus Scleroderma Dermatomyositis Constitutional Fatigue
Weight loss Cutaneous Butterfly (malar)
phenomenon Sharply demarcated pallor resulting
from the closure of digital arteries Digital cyanosis of the fingertips in a patient
with primary Raynaud phenomenon Tightening of skin
of the face and
Myalgia Tightening of the skin in the face, with a characteristic beaklike facies and paucity of wrinkles. Sclerodactyly with digital ulceration, loss of skin creases, joint contractures, and sparse hair. Muscle weakness
(symmetric, proximal) Gottron's sign
Shawl & V sign
Calcinosis An erythematous, scaly eruption over the extensor surfaces of the metacarpophalangeal joints and digits in a patient with dermatomyositis. A reddish-purple eruption on the upper eyelid (the heliotrope rash), accompanied by swelling of the eyelid in a patient with dermatomyositis. This is the most specific rash in DM, although it is only present in a minority of patients. Erythema that resembles the shawl sign but is seen in a variety of other cutaneous areas, including the malar region and the forehead. Multiple areas of capillary loop dilatation Periungual erythema A roughening and cracking of the skin of the tips and lateral aspects of the fingers, resulting in irregular, dirty-appearing lines that resemble those of a manual laborer Changes in the scalp resembling psoriasis Erythematous linear streaks,
probably induced by scratching
pruritic skin. Arthritis Inflammatory
Only few joints
affected Patient with long-standing lupus has developed subluxation at the MCP joints and swan neck deformities of her fingers. These deformities are reducible (probably being due to lax tendons) and x-rays reveal no erosions or cysts, both of which differentiate these findings from those in rheumatoid arthritis. True, inflammatory
arthritis uncommon Polyarthritis Haematologic Anaemia (haemolytic)
thrombosis Cardiopulmonary Pleuritis
Arrythymias Interstitial lung disease
Myocarditis Renal Nephritis Gastrointestinal Peritonitis
LES Weakness of the striated
muscle (upper 1/3)
lead to dysphagia,
aspiration Neurologic Organic brain
Renal crisis/failure Opthalmologic Keratoconjunctivitis
sicca Antinuclear Antibodies