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Multiple Myeloma

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by

Ivy Liu

on 14 February 2013

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Transcript of Multiple Myeloma

•6,070 of those deaths will be men, and 4,640 will be women by: Ivy Liu and Sophie Leary
Honors Biology
6th Period Multiple Myeloma Multiple Myeloma Symptoms What is it? The symptoms may vary from each person, and they usually do not appear until later on in the disease. Some of the most major problems include:

high amounts of calcium in the blood- which can also cause thirst, constipation, nausea, confusion, and loss of appetite

kidney failure

fatigue related to anemia

fractures and damage to the bone

chronic infections

weight loss

weakness in the legs Treatments and Medication Survival Rates Discovery The first known case of multiple myeloma was diagnosed in 1844 in England on 39 year-old Sarah Newbury; however, multiple myeloma has been detected in the skeletons of Native Americans, meaning it's been around for much longer. During her autopsy, much of her sternum contained a red substance, and later, Dr. Otto Kahler discovered this substance in the ribs and vertebrae in an autopsy of Thomas McBean. The term "multiple myeloma" wasn't used until 1873 by a Russian doctor named Von Rustizky. He saw eight bone marrow tumors and described them as multiple myelomas. Multiple myeloma is caused by an irregular plasma cell in the bone marrow, but the actual cause of this is still unknown. Statistics Multiple myeloma is a cancer where a group
of plasma cells become cancerous and multiply
rapidly, causing the plasma cell count to be
higher than normal. There are three main types of treatment for multiple myeloma
• Chemotherapy- This treatment partially controls multiple myeloma, but rarely leads to remission.

• Newer Drugs — Newer drugs such as thalidomide are important options for treatment. They are recommended for either newly diagnosed patients or patients who have had a failed chemotherapy or transplant treatment.

• Stem cell transplantation — A stem cell transplantation can be done using the patient's own stem cells or the cells from a close relative or matched unrelated donor. Most multiple myeloma transplants are autologous. These transplants can prolong life in selected patients, but may need to be performed multiple times. •Men are more likely to get multiple myeloma than women. •About 22,350 cases will be diagnosed
this year •This year, 10,710 multiple myeloma deaths
are expected to occur. •Multiple myeloma occurs most commonly in people over the age of 60 Sources Kyle, Robert A. "Multiple Myeloma." Blood. 111.6 n. page. Web. 10 Feb. 2013. <http://bloodjournal.hematologylibrary.org/content/111/6/2962.full>.
Mayo Clinic staff, . "Multiple myeloma." Mayo Clinic. Mayo Foundation for Medical Education and Research, 16 Aug 2011. Web. 02 Feb 2013. <http://www.mayoclinic.com/health/multiple-myeloma/DS00415>.
. "Multiple Myeloma." MedicineNet.com. MedicineNet, Inc.. Web. 01 Feb 2013. <http://www.medicinenet.com/multiple_myeloma/article.htm>.
Rajkumar, Vincent S. "Multiple myeloma treatment (Beyond the Basics)." Wolters Kluwer Health: UpToDate. UpToDate, Inc., 16 Dec 2011. Web. 02 Feb 2013. <http://www.uptodate.com/contents/multiple-myeloma-treatment-beyond-the-basics>.
Siddiqui, Imran. "Multiple myeloma." Ayub Medical College. N.p.. Web. 10 Feb 2013. <http://www.ayubmed.edu.pk/JAMC/PAST/15-1/Imran Myeloma.htm>. The survival rates of multiple myeloma vary depending on what stage the patient is diagnosed with. •Stage 1-Patients have an expected 62 month survival rate. That is a little over five years.

•Stage 2- Patients have an expected 44 month survival rate. That is a little over three and a half years.

•Stage 3- Patients have an expected 29 month survival rate. That is less that two and a half years. Family Member My grandfather, John Leary was diagnosed with stage four multiple myeloma in 2003. He was initially given six month to live. However, he decided to fight it, and joined a research study in Little Rock, Arkansas. While there he took experimental drugs,numerous rounds of chemo, and endured four stem cell transplants. He was the only patient to survive four transplants, and he lived longer than any other stage four patient. He lived for seven years. His doctors considered him a miracle, but we knew that it was his strong spirit.
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