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Penta prezi

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zeel kamdar

on 4 April 2013

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Transcript of Penta prezi

Pentavalent Vaccine Vaccine Efficacy :

Provide 85 to 95% protection after completion of the schedule.

The vaccination reduces nasopharyngeal colonization of the organism, leading to substantially greater reduction in disease transmission.

Duration of Protection :
Hib vaccine provides protection for at least 15 years.

A booster dose is not recommended. New MAMTA Card Any questions…???

Thank you Recommended optimal age for pentavalent vaccination is

A) 6 week- 12 months
B) 15-18 months
C) At birth
D) None Local reactions- Redness, swelling and pain at the site of injection may occur in as many as 25% of those who have been vaccinated

Such reactions usually start within 1 day after immunization and last for 1–3 days

Systemic reactions- LPV has not been associated with any serious adverse effects. Rarely fever and irritability for short duration

The rate of AEFI is not any higher than when DPT is given alone Adverse Events Following Immunization (AEFI) Dosage and Route 0.5 ml – intramuscularly

Antero-lateral aspect of the mid thigh in infants 1. DPT stands for….???

2. Route of DPT??
a)Intra Muscular
b) Sub Cutaneous
c) Intra Dermal
d) Intra Venous Revision What will be the dose of pentavalent vaccination?

A) 0.1 ml
B) 0.5 ml
C) 0.1 Ul
D) 0.5 Ul Contraindications There are only 2 major contraindication for administration of Pentavalent vaccine:

Severe allergic reactions
To a component of the vaccine following a previous dose of Hib/Pentavalent vaccine.

Moderate to severe acute illness
However minor illnesses such as upper respiratory infections (URI) is not a contraindication to vaccination. Vaccination Schedule Three dose primary series will be considered routine
The first dose is given to children at six weeks of age or older. Storage Kept at temperature between 2 - 8 degree Celsius (in side the basket of ILR)

Conditioned ice packs should be used during transportation.

Should be protected from direct sunlight By the end of the session, you will get to know Brief about Haemophilus influenzae b (Hib)
Pentavalent Vaccine in Universal Immunization Program in India Which type of Haemophilus influenzae associated with serious infections in children?

A) g
B) a
C) e
D) b Lets try some MCQ’s MUSCLE SUB CUT DERMIS EPIDERMIS IM
90 deg angle INTRADERMAL
10-15 deg angle SUBCUTANEOUS
45 deg angle Photo of ILR CFR (Case fatality ratio) for meningitis - 10 to 30 %


25-30% of Hib meningitis survivors suffering from long term neurological sequelae


It has been estimated that control of Hib related diseases will reduce IMR by 4% points.


(WHO prequalified the vaccine - Sept 2006) Diagnosis –
Bacterial culture
Latex Agglutination Test
Polymerase Chain Reaction (PCR)

The culture is done on sterile fluids like CSF or blood.

Treatment –
Not always effective
Antibiotic resistance is severe problem
So Immunization against Hib is cost effective strategy Formulations of Pentavalent Vaccine Different formulations of liquid or lyophilised (dried powder), stand alone (mono-valent) and combination (DPT+Hib, DPT+HepB+Hib) forms.

The formulation which is provided in UIP in India is Liquid Pentavalent vaccine (LPV).

The vaccine is having 5 antigens (DPT+ HepB+ Hib) in a single formulation.

One LPV vial contains 10 doses (0.5 ml each) Hemophilus Influenza Type B According to WHO estimates, annually 2.4 to 3.0 million cases of Hib disease occurs in India, with total deaths estimated to be at 72,000 *

In India, Hib diseases contributes to 40 to 50 % of meningitis cases and 25 to 30 % of pneumonia cases in children aged less than 5 years.

Hib is the most common cause of meningitis and the second largest cause of pneumonia (after streptococcal pneumonia) in India

* Source: (Watt et al, 2009; NTAGI - National Technical Advisory
Group of India Sub-committee, 2009). Gram Negative coccobacillus affects only humans Six types (a,b,c,d,e,f and g)

Hib accounts for 90% of serious Haemophilus influenzae infections in children

Modes of Transmission –
Droplets of saliva,
Sharing of toys


Risk Group-
Children between the ages of 4 to 18 months


Diseases caused by Hib –
Bacterial Meningitis
Inflammation of the lungs
Others - septicemia, septic arthritis,
osteomyelitis, epiglottitis Hib Overview Revision Revision
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