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On Demand Drug delivery using Self Assembled Hydrogels

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smruthi suryaprakash

on 9 May 2012

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Transcript of On Demand Drug delivery using Self Assembled Hydrogels

1 1 On Demand Drug delivery using Self Assembled
Hydrogels Smruthi Suryaprakash Rheumatoid Arthritis Inflammatory conditions

2.5 million or 1% of US adult population suffer from Rheumatoid arthritis Rheumatoid Arthritis Auto immune Disease
Inflammation of the synovial membrane and soft tissue around the joint.
Variable disease activity
Exacerbations
Remissions Current system of treatment Drugs
COX-2 Inhibitors
High Systemic Toxicity
Vioxx and Bextra removed from market Drug Delivery depots
Poor physical stability within the joints Intra articular Injection
Rapid clearance
t1/2 ≈ 0.1-6 h Introduction Current System of Treatment Bolus Delivery Controlled Delivery Benchmark for Novel Therapeutics Drug requirement for Rheumatoid Arthritis Controlled Drug Delivery Exacerbation Remission Benchmark for novel therapeutics Develop Safe regulation which has low regulation bar for approval Increase the Drug Loading How can we improve? Drug release in response to diseased state Increase drug loading
Self assembled hydrogels Safe Formulation
Ascorbyl Palmitate Self assembly low molecular weight
amphiphilic molecule Nanofiber Hydrogel GRAS- Generally Recognized As Safe Drug release in response to diseased state
Enzyme responsive drugs Vitamin C ester Ascorbic Acid Palmitic Acid Antioxidant food additive Results Gelling conditions Scanning Electron Microscope Optical Images Bright Field Fluorescence Overlay On Demand Drug Release Drug Release in response to the enzyme Stable in vivo Bright field Fluorescence Overlay Future Direction Conclusion Study the various other applications
Cancer
Wound Healing
Gastro intestinal disease Study the therapeutic Efficiency using the actual drug (Triamcinolone acetonide) Proof of concept on demand drug delivery shown Stable in Healthy joint in-vivo Forms Gel under multiple conditions Dr. Praveen Kumar Vemula Dr. Jeffrey M Karp Diseased Cell Self Assembled fibrous
hydrogel Disassembly of fibers and release of drug Thank You! Acknowledgment

Nanyang Technological University
Dr. Jeffery Karp
Dr. Praveen Kumar Vemula
Full transcript