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Ibuprofen History

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brandon lee

on 4 April 2015

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Transcript of Ibuprofen History

Ibuprofen was developed and discovered as a drug by the Boots Company. The leaders of the team were Dr Stewart Adams and his colleagues John Nicholson and Colin Burrows but hundreds of people were involved.
1958 After some 600 compounds had been made and screened for activity, a promising compound code named BTS 8402 is given a clinical trial (ie a trial on patients). It is found to be no better than aspirin.

1961 A patent is filed for the compound 2-(4-isobutylphenyl) propanoic acid - later called ibuprofen.

1964 Ibuprofen is selected for further development.

1966 Clinical trials of ibuprofen take place at the Northern General Hospital in Edinburgh and show its anti-inflammatory effect in patients.

1969 Ibuprofen is launched in the UK on prescription only.

1983 Because of its safety record, ibuprofen is made available without prescription.
Work started in the 1950s to find a drug to treat rheumatoid arthritis that had fewer side effects than aspirin. However ibuprofen was not launched until 1969. 1955 The discovery is made that anti-inflammatory drugs reduce inflammation of the skin caused by ultra-violet light. This gives a simple screening test for new chemical compounds (called new chemical entities or NCEs in the jargon) that the research chemists produced.
Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) that is commonly used for the relief of symptoms of arthritis, fever, primary dysmenorrhea (menstrual pains), and as an analgesic (a medication given to reduce pain without resulting in loss of consciousness). Ibuprofen also has an antiplatelet effect (protects from blood clots), though less than aspirin.
What is an NSAID (non-steroidal anti-inflammatory drug)?
Non-steroidal anti-inflammatory drugs, or NSAIDs, also known as non-steroidal anti-inflammatory agents/analgesics (NSAIAs) or non-steroidal anti-inflammatory medicines (NSAIMs), are medications with analgesic, antipyretic (something that reduces a fever), and in higher doses anti-inflammatory effects.
How does ibuprofen work?
Ibuprofen blocks the production of prostaglandins, substances our body releases in response to illness and injury. Prostaglandins cause pain and swelling (inflammation); they are released in the brain and can also cause fever.

Ibuprofen's painkilling effects kick in soon after a dose is taken. Ibuprofen's anti-inflammatory effects can take a bit longer, sometimes a few weeks.
Ibuprofen Structure

Molecular Formula: C13H18O2
Molar Mass: 206.29 g/mol
Melting Point: 168.8°F (76°C)
Boiling Point: 157 °C (315 °F)
Density: 1.03 g/ml g/cm3
Ibuprofen History
Site Created by Brandom Mendoza
Chemical Compound Project

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