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Acyclovir eshraket saydala ASU

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Eshraket khair pharmacy ASU

on 10 August 2013

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Transcript of Acyclovir eshraket saydala ASU


To become effective, acyclovir must first be changed to
acyclovir monophosphate
by an enzyme that is only found in viruses, called
thymidine kinase (TK)
.

So the inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme
thymidine kinase (TK)
encoded by
HSV
and
VZV
not by human cell.



acyclovir monophosphate
is then converted to its active
triphosphate
form by
human enzymes
found inside the cells.


acyclovir triphosphate
stops replication of herpes viral DNA. by :
- competitive inhibition or inactivation of viral DNA polymerase.
- incorporation into termination of the growing viral DNA chain.


what is
Acyclovir ?

Generic Name:
Acyclovir
Brand Names:
Zovirax

- An antiviral drug.

- used to treat infections caused by
herpes
viruses.

- Acyclovir will not cure herpes, but it can lessen the symptoms of the infection. so that the body can fight off it .

Herpes viruses
- A large family of
DNA
viruses that cause viral diseases .

-
HSV-1
facial cold-sores
-
HSV-2
(genital herpes)
-
VZV
chicken-pox & shingles
Mechanism of Acyclovir action
Acyclovir
is a synthetic nucleoside analogue active against herpes viruses
summary
"
Acyclovir
"
our 2nd target
Full transcript