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Cystic Fibrosis and the Cell Membrane

The disease, Cystic Fibrosis, at a cellular level.

Charlotte Khamnei

on 8 October 2015

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Transcript of Cystic Fibrosis and the Cell Membrane

The Cell (Plasma) Membrane
Result Of The Cell Not Functioning
Cystic Fibrosis
The cell membrane's main functions are to control what goes in and out of the cell and maintain homeostasis.
The cell membrane is made of a phospholipid bilayer.
The bilayer has a hydrophobic interior layer, which does not allow anything with a charge into the cell.
The bilayer has transmembrane integral protein channels that allow molecules to enter the cell.
Primarily Affected
What is Going Wrong Inside the Cell?
Inside of the cell, the ion channels in the cell membrane are malfunctioning due to the mutated CFTR protein. This causes salt to get trapped inside of the cell. The salty cellular interiors take moisture away from surrounding tissues, drying up mucus and thickening it.
The organs that are most commonly affected are the lungs. Other organs can also be affected, but it depends on the mutation of the CFTR (Cystic Fibrosis Trans-membrane conductance Regulator) protein.
Cystic Fibrosis is a disease that affects more than 30,000 people (mainly children).
People with Cystic Fibrosis live from 4-35 years (average of 29 years).
Symptoms of Cystic Fibrosis include: very thick mucus in the lungs, that could cause choking; clogged pancreas; and salty sweat.
Cystic Fibrosis
and the
Cell Membrane

The Disease, Cystic Fibrosis, at a Cellular Level
Because the cell is not functioning the
way there are consequence for the body:

The too sticky and thick mucus coats lungs and pancreas and makes breathing sometimes impossible.
The person might have salty skin.
Colds can be deadly because of the extra mucus that is generated.


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