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Transcript of Mainstream Medicine
-Should you still blindly trust the drug companies and take their pills once you are sick?
NO, wake up!
Do not include the results from patients who did bad
Torture the data
Try to see if the drug has had good effects on a certain subgroup
Ignore the protocol entirely:
Assume that every correlation proves causation (while there may be
many other factors that have generated the outcome)
Try every button on the computer
Run your graphs through several statistical software until a pleasing outcom is managed
Behnam Azizi - Bruce Zhang - Edison Chen
How the drug industry can trick you
- Why is mainstream medicine evil?
- How the the drug industry deceive people into believing that their drugs are useful.
- Actions that we can take.
Is it evidence-based?
- How much medical practice/activity is evidence-based?
13% of all treatments have a good evidence.
21% of the all treatments are just likely to be beneficial
-Hospital/clinic diagnosis(medical activity) is roughly 50%-80% evidence-based
- Sometimes, when they get positive results, instead of just publishing them once, they publish them several times.
- Test drug their against useless drugs that
have no clinical value (e.g., placebos)
- Use very high or very low dosages of the
competing drug so patients either do not
experience cure or experience the
side-effects of the competing drug
What to do to
- How the effectiveness of a drug is measured
for example, if a drug is supposed to reduce cholectrol and resultantly cardiac deaths, measuring only the blood cholestrol levels
(focusing on the easier part rather than the real-world problem)
- Drug companies tend to focus on the positive outcomes of their trial
(negative results either not mentioned or mentioned briefly)
- If the result of the trials are negative, doing more trials and achieving more positive outcomes can compensate for the negative results
- Tricks used in statistical analysis (discussed briefly in next slide)
- An anti-depressant drug with several side effects including inappropriate hypersecretion of antidiuretic hormone, and anorgasmia
- The 3000-subject review mentioned 23 side-effects for the drug but not anorgasmia
According to the researchers, the 23 other side-effects where more important (therefore they were the only ones to be mentioned)
- Positive results tend to be more appealing therefore have a higher chance of being published in scientific journals
- eliminating the symptoms is not necessary equivalent to treatment
- Publishing the data in positive section of the graphs rather than the whole normalized graph
Case Study: SSRI
- In different places, in different forms, so that it looks as if there are lots of different positive trials.
- The results for many individual patients had been written up several times, in slightly different forms, in apparently different studies, in different journals.
- In 1995, only 1 per cent of all articles published in alternative medicine journals gave a negative result
Graphs with Normal Distribution
The graph of many natural experiments tend to follow a similar pattern (i.e., bell-shaped normalized graphs)
Example: Grades of students. The number of students with very high or very low grades is very low, while 98% of data falls within one standard deviation of the average grade.
Medicine production & drug companies
-There are 3 trails of making a new medicine.
-However, drug trails are very expensive. drug companies support them and "control" them. (how it is researched & what result can be reported.)
Drug company's selfishness
-Drug companies make new medicine is not for the public treatment, but the profit they can earn.
- they apply the patent for the drugs and use it to make money.
-Also, there are a lot of "me-too" drugs in the market.
-Some Chinese drug companies use the materials of making shoes to produce capsules.（ over proof chromium（Cr)）
-Nobody has a patent on magnesium because it has no commercial value. even it can treat Eclampsia.
-The companies always hide the Side-effects of their drugs.
-Example: Anti-arrhythmic drugs: At the peak of their use in the 1980s, anti-arrhythmic drugs were causing comparable numbers of deaths to the total number of Americans who died in the Vietnam War.
A cheap solution
-The single cheap solution that will solve all of the problems in the entire world
-‘moving the goalposts’：A clinical trial register, public, open, and properly enforced
If you registered a trial, and conducted it, but it didn’t’t appear in the literature, it would stick out like a sore thumb. Everyone, basically, would assume you had something to hide, because you probably would.
-The budget for direct-to consumer advertising in America has risen twice as fast as the budget for advertising to doctors.
-Customers are much easier fooled because the adverts always catch their demands.
Example of deceptive advertising
Wait, what the....???
-In order to make the maximum profit, some business men in drug company betray their morality. They never care about the harm they bring to the public & society.
-Some behaviors of companies are unethical, even illegal.
-How the drug companies can deceive you?
Please be critical.
- Pay more attention when you want to buy drugs.
- Do not rely on the drugs blindly.
- Eliminating the symptoms does not necessarily mean treatment.
Need an example?
1. what do you think about the drug companies? are they evil? why?
2. How can the government manage these companies to make our world better?
3. What changes can we make in the drug industry to improve quality of medicine?