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Polymeric Nanoparticles

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Aneeka Kamal

on 6 February 2015

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Transcript of Polymeric Nanoparticles

Polymeric Nanoparticles
Preparation of nanoparticles
In vitro & vivo toxicity studies of PNP'S
Polymeric nanoparticle-encapsulated curcumin:a novel strategy for human cancer therapy
Curcumin
Introduction

Outline
Introduction
Polymers used in preparation of nanoparticles
Methods of preparation
Pros & Cons
Article :)
Polymers used in preparation of nanoparticles
Natural Hydrophilic
Synthetic Hydrophobic
Proteins
Polysaccharides
Examples
Examples
2 methods" Dispersion of preformed polymers" or "polymerization of monomers"
Several ways are used to achieve each method
Dispersion of preformed polymers
Solvent evaporation
Nanoprecipitation
Dialysis
Salting out
Polymerization of monomers
Emulsion
Mini-emulsion
Micro-emulsion
Ionic gelation
Pros
&
Cons
Delivers a higher concentration of pharmaceutical agent to a desired location.
Polymeric nanoparticles can be easily incorporated into other activities related to drug delivery, such as tissue engineering.
Has significant advantages over traditional oral and intravenous methods of administration in terms of efficiency and effectiveness.
Particle-particle aggregation makes physical handling of nanoparticles difficult in liquid and dry form.
Very costly formulation with no low yield
Salting Out
Polymers such as PLA and poly(metacrylic acid) are used to produces polymeric nanospheres
Advantage :
can used for heat sensitive substance
minimizes stress
Ionic gelation
Biodegradable Natural polymers such as chitosan, Sodium alginate & gelatin are used to prepare Polyeric nanospheres
What are PNP’s? They are solid colloidal particles with diameter ranging from 1 to 1000 nm.
PNP’s
They have been investigated especially in drug delivery and drug targeting owing to their particle size.
Nanosphere
Nanocapsule
Gelatin
Chitosan
Sodium Alginate
Albumin
Polylactides(PLA)
Poly(metacrylic acid)
Polyglycolides(PGA)
Has anti canceral properties
Free curcumin has limited properties due to its low solubility & minimal bio activity
PNP based drug delivery shows improved anti-canceral properties
Abstract
Preparation of PNP'S & loading Of curcumin
Copolymers were prepared using NMP
PNP's were achieved by Dialysis
FT-IR,H-NMR were performed to confirm complete polymerizaton
DLS & TEM were performed for size characterization of PNP
Cell Viability (MTT) assays was performed against a series of pancreatic cancer lines
Nanocurcumin consistently showed comparable efficacy compared to free curcumin
"Polymeric nanoparticle-encapsulated curcumin"
Savita Bisht, Georg Feldmann, Sheetal Soni, Rajani Ravi, Collins Karikar,
Amarnath Maitra and Anirban Mai

Aneeka Zaheen Kamal
500213007

Chemistry Dept
Chem 614

A PNP encapsulated curcumin was synthesized Coplymerization
Conclusion
Successfully synthesized PNP encapsulated curcumin
Nano-curcumin has higher efficacy than free curcumin
Non-toxicity was demonstrated
Nano-cucumin opens up doors for systematic therapy
Thank you :)
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