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cancer gastric

factori de risc
by

Monica Borza

on 18 April 2010

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Transcript of cancer gastric

Cancer GASTRIC Epidemiologie Factori de risc Afectiuni gastrice
predispozante
Helicobacter pylori

oncogen de ordinul I (OMS)

determina gastrita atrofica cu metaplazie intestinala
factor de risc atat pentru adenocarcinom ( tip intestinal sau difuz ) cat si pentru limfomul gastric malign
eradicarea sa in tarile avansate a determinat incidentei CG Alimentatia

continut crescut in nitrozamine creste incidenta CG
bogata in vitamina C & A (fructe si legume proaspete) scade incidenta Factor genetic

predispozitie familiala
alterari cromozomiale - deletii ale cromozomilor 5q, 17p,18q
alterari ale unor oncogene dominante Nivel socio-economic GASTRITA CRONICA ATROFICA

frecvent determinata de HP
apar leziuni displazice

GASTRITA din boala MENETRIER / GASTRITA HIPERTROFICA GIGANTICA

hiperplazia celuleor mucosecretorii ce alcatuiesc stratul protector de mucus al stomacului

POLIPI ADENOMATOSI GASTRICI

stare precanceroasa, mai ales cei mari
polipectomie la cei > 1 cm

REZECTIE GASTRICA

la peste 15 ani de la interventie
gastrita

ULCER GASTRIC

ulcer cancerizat (malignizat) - cancer ulcerat
gastrita satelita distributie geografica uniforma
rasa alba
varsta >
barbati: femei
1:1
nivel socio-economic crescut Asia Est, Europa Est, America Sud
rasa neagra
sex masculin
varsta <
nivel socio-economic scazut Prevalenta - zona geografica, obiceiuri alimentare
Raport barbati:femei = 2/3:1
Frecventa creste cu varsta
tip I - cripte longitudinale cu celule in cupa si de absorbtie bine dezvoltate
tip II - epiteliu intestinal bine diferentiat
tip III - cripte sinuoase cu celule imature si celule in cupa ce contin sulfomucine smoking &alcohol
vagotomy
partial gastrectomy
anti inflamatory drugs
having other cancers
radiation exposure
reduced immunity
body weight
hormone replacement therapy (HRT) tip I - cripte longitudinale cu celule in cupa si de absorbtie bine dezvoltate
tip II - epiteliu intestinal bine diferentiat
tip III - cripte sinuoase cu celule imature si celule in cupa continand sulfomucine
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