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Sickle Cell Anemia

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by

Asha Edwards

on 5 June 2016

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Transcript of Sickle Cell Anemia

Causes
Treatments
Hydroxyurea: A drug that gives red blood cells hemoglobin, allowing them to become more flexible. Reduces number of crises and blood transfusions needed for a patient.
Symptoms
Symptoms include:
Delayed growth because of a lack of healthy red blood cells
Unexplained episodes of pain
Vision problems
Anemia (shortage of healthy red blood cells)
Diagnostic Tests
Unborn Babies: amniotic fluid is taken from mother's womb and tested for sickle cell trait

Newborn Babies-Adults: Blood test for hemoglobin S
How Common?
Frequency in Population
Sickle Cell Anemia
Piper MacDonald,Sahara Thomas,and Asha Edwards

Inherited?
In order to inherit the sickle cell disease, the offspring must receive not one, but two sickle cell traits which will come from both parents each. Aa's wont have SCA in their phenotype. Inheriting the sickle cell diseases requires two sickle cell traits.
The trait is located on
chromosome 11
.
What is Sickle Cell Anemia?
Sickle Cell Anemia is a genetic disorder that causes blood cells to become misshapen and dysfunctional.
These cells can stick to the walls of blood vessels and prevent oxygen from going where it must in the body.
A Personal
Account
What did we Learn?
QUIZ:Question 1
Bone Marrow Transplants
Blood Transfusions
In the U.S SCD affects about:
100,000 Americans
1 out of 4,000 infants annually
1 out of every 365 African-American births.
1 in 13 Black or African-American born with sickle cell trait.
If test is +, more tests are done to determine if you have both one or both alleles for sickle cell.This is determined by how many sickle cells are in the body.
Sickle Cell Anemia is caused by a gene mutation that is passed through autosomal recessive inheritance. The gene that tells your body to make hemoglobin becomes mutated, and the abnormal hemoglobin made causes blood cells to be misshapen and sticky.
A a
A

a
AA

Aa

Aa

aa
Overall, we learned that sickle cell anemia damaged a cell rather than a tissue.Instead of a chemical change being harmful to the makeup of a tissue, the health problems usually are caused by cells causing physical blockage in vessels.
Tionne Watkins
(T-Boz) TLC Singer
SCA is caused by:
A.
lack of iron in diet
B.
exposure to radiation
C.
mutations in hemoglobin
D.
cells dividing improperly during mitosis, changing the shape
Question 2
What sort of trait is SCA?
A
. Dominant, sex linked
B
. Recessive, sex linked
C
. Dominant gene
D
. Recessive gene
Personal Account
(cont'd)
Question 3
Question 4
All of the following are symptoms of SCA EXCEPT...
A
- stunted growth
B
- vision problems
C
- loss of appetite
D
- unexplained pain
Which of the following CANNOT be used to treat SCA?
A
- bone marrow transplants
B
- blood dialysis
C
- Hydroxyurea
D
- blood transfusions
Tionne Watkins experienced severe pains in her hands and legs as a result of SCA, and was told that she would not live past 30.
As an artist, life was difficult with the disease, as she was frequently hospitalized.
She learned to take better care of her health, and is now 38 with a daughter who is a carrier.
Sources
Works Cited
What Is Sickle Cell Disease? - NHLBI, NIH. NIH, n.d. Web. 02 June 2016.
Data & Statistics. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 2016. Web. 02 June 2016.
How Do People Get Sickle Cell Disease? How Do People Get Sickle Cell Disease? Harvard Medical, n.d. Web. 02 June 2016.
Sickle Cell Disease: What Is It? Sickle Cell Disease: What Is It? N.p., n.d. Web. 02 June 2016.
Sickle Cell Anemia. Symptoms. Mayo Clinic, n.d. Web. 02 June 2016.


THANK YOU! WHAT DID YOU LEARN???
In the 70's, most people with SCD had life expectancies of 14 years. Now, patients can live to their fifties.
But WAIT! There's even more!



Basically, all organs and tissues that need healthy blood become damaged.
Swelling of hands and feet.
Frequent Infections
Abdominal swelling
Fatigue
Overall Malaise
Full transcript