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PICO PRESENTATION

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by

Danny Marsh

on 28 July 2015

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Transcript of PICO PRESENTATION

PICO
Population: Adult patients requiring liver transplants

Intervention: Receiving a living donor liver transplant (LDLT)

Comparison: Receiving a deceased donor liver transplant (DDLT)

Outcome: To have no reoccurring liver disease

Study #1
Study Title: Hepatocellular Carcinoma Recurrence and Death Following Living and Deceased Donor Liver Transplantation

Purpose: The purpose of this study was to compare the reoccurrence of Hepatocellular Carcinoma in living donor livers to dead donor liver donors

Dates of Study: The dates of the study were between the years 1997 and 2003


Study #1 Continued
Study Location: This study was conducted on patients from 9 transplant centers in America participating in the Adult to Adult Living Liver Transplant Study

Sample Size: The sample included 106 adult patients who needed a liver transplant. 58 who received a liver from a live donor, 34 who received a liver from a deceased donor, and 14 who did not receive a transplant. There is no specific race associate with these clients but LDLT recipients have an average age of 54.5 while DDLT recipients have an average age of 51.7
Study #2
Study Title:Living donor liver transplantation versus deceased donor liver transplantation for hepatocellular carcinoma: Comparable survival and recurrence

Purpose: The purpose of this study is to compared the overall survival rates and the rates of hepatocellular carcinoma recurrence after LDLT and DDLT

Date of Study: This study took place between January 1996 and September 2009
Study #2 Continued
Study Location: This study was completed only on patients from Toronto General Hospital in Toronto Canada

Sample Size: This sample included 345 patients of a variety of ages and race who had hepatocellular carcinoma and were eligible for liver transplants. 287 patients received DDLT while 58 patients received LDLT. The groups were similar in respect to most clinical parameters with respect to median transplant wait times which was 3.1 months for DDLT and 5.3 for LDLT.
PICO QUESTION
Is there a higher recurrence of liver disease in patients who received a living donor liver transplant compared to a deceased donor liver transplant?
PICO PRESENTATION
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