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in March 2013, Explore the Future for Monitor Deloitte

Raymond McCauley

on 22 March 2013

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Transcript of Biohacking

Human Genome Project
2001, 13 years

Celera Genome Project
2001, ~3 years

454 James Watson Genome
2007, ~2 months

Illumina Yoruban Trio
2008, 6 weeks

Illumina Consumer Sequencing
May 2009, 2 weeks

Illumina Consumer Sequencing
June 2010, 1 week
$9500 = $19500

Illumina Consumer Sequencing
June 2011, 1 week

Personal Genome Project (Various)
Jan 2012, 3-7 days
$2000 Singularity
University Raymond McCauley
for Explore the Future for your attention raymond@raymondmccauley.net DNA Structure DNA Sequencing Biology now falls under Moore's Law Raymond McCauley biochemistry
electrical engineering
computer science bioinformatics
nanotechnology genetic engineering DNA sequencing DISCLAIMER These are my opinions and are not intended to reflect the views of any group or organization with which I may be affiliated. Reading DNA twitter: @raymondmccauley
email: raymond@raymondmccauley.net DNA Sequencing Economics Cost Exponential Biosciences Creative Commons 3.0 license
Attribution-NoDerivs 3.0 systems
biology DNA Sequencing Tech 5X ~ 10X

Computer Tech
1.5X ~ 2X past: Biotech Chair, Singularity U
Co-Founder, BioCurious
Principal, Exponential Biosciences

Current Research Areas:
Personal Genomics
Cancer Sequencing 2020 2016 2014 2020 = = = = Watson, Crick & Franklin Source: National Human Genome Research Institute, Exponential Biosciences Synthetic Biology DNA Synthesis What will we make? Genetic Engineering
Software Development Innovation Lessons
from being in
an exponential business Find an exponential trend,
then hitchhike A prototype beats a plan Product Development Process (PDP) typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk is now as easy as typing Nothing fades faster than last year's technology 2008
$500K Today
$1 Remember... In the future,
if it is made out of atoms,
you will make it with biology. What does your industry
make or use? Genetic Engineering Human PGD
mitochondrial therapy
germ line therapy Biology as Economy Biology as Technology 1/3 World Economy Medicine Agriculture Energy Manufacturing "The GM debate is over... We no longer need to discuss whether or not it is safe — over a decade and a half with three trillion GM meals eaten, there has never been a single substantiated case of harm. You are more likely to get hit by an asteroid than to get hurt by GM food.” - Mark Lynas, GMO crop burning environmental activist "...There is no more risk
in GMO food than conventionally
farmed food." - Anne Glover,
European Commission’s
Chief Scientific Advisor Digital Agriculture versus Singularity
University version 3:
Illumina Custom OmniExpress+ BeadChip
Assays about 1,200,000 SNPs Your chance to try it...
Consumer access to research tool
"Recreational genomics"
Disease risk, carrier status, genealogy Gene Scan Gene Sequence most interesting/best known
1.2 million bases
0.04% all
3 billion bases
100% DNA Microarrays or need to unmake? People Teams Interdisciplinary Innovation Lessons
from being in
an exponential movement Find an exponential trend,
then hitchhike A prototype beats a plan Product Development Process (PDP) typical product:
18 month development cycle,
9 month market life

make new & rev old products
core team leaders involved from start
phase-gated milestones
manage technical and business risk Nothing fades faster than last year's technology 2008
$500K Today
$1 People Teams Interdisciplinary = DNA sequencing
and synthesis prices
continue to plummet Synthetic
Biology * Hype Cycle but... Raymond McCauley @raymondmccauley +1-650-776-4561 Thank you GMO Biohacking: Life is the New Black Anxiously watching IP Hopefully watching Crowdfunding A gentle
introduction... Democratizing
Biotech Scaling Problems Cells are not
computers Democratization
Biotechnology How fast can you get to
"Hello World"
with 2 guys & a laptop in a garage? a hackerspace for biotech

First and largest biohacker lab in the world

Committed to making biotech
accessible, affordable, and open to everyone

a place to "experiment with friends"

501c3 not-for-profit all-volunteer community lab, supported by monthly memberships and classes Let's do that for biotech iGEM 2004 international
competition iGEM World Jamboree 2010 Who wants to be a Genetic Engineer? We teach
classes... bioprinter project We build things.. OpenPCR $599 DNA Copy Machine We mentor the
next generation
of scientists
and technologists We support inventors
and entrepreneurs We take safety
and security
seriously In the last year,
19 startup companies
have done work
and recruited partners
at BioCurious We build
community BioCurious/FBI
Joint Conference on
June 12-16, 2012 http://openpcr.org/ Garage Labs When we talk about garage labs
in Silicon Valley, we aren't kidding... Helixis Real Time PCR Industry: $30,000
Helixis: $13,900 How does
sound? The Biotech
is Here! If you've got: Who wants to build something? Dremelfuge Centrifuge = $57 >$500 on Shapeways used, on eBay Research Tools Better, Cheaper, Faster US$750000, a PhD in molecular biology, and a fully equipped lab Outliers What do
we do? iGEM Inaugural Competition, 2004 More tools in more hands
More Breakthroughs We are everywhere... currently tracking
23 community labs
405 individual labs
on 6 continents Tokyo Biotics
Tokyo JP

DIYbio Singapore
Singapore SG

Lausanne CH

Switzerland CH
http://hackteria.org/ Movements to Watch Health Hacking Biohacking
Citizen Science
Garage Biology Closing Thoughts zebra mussel glue Selected Projects possibilities... The Tulip Project qPCR
barcoding for strain ID
Genetic Engineering
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