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MAKAHIYA (Mimosa pudica) ROOT EXTRACT AS WOUND HEALING AGENT

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by

Gazelle Garcia

on 13 January 2013

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Transcript of MAKAHIYA (Mimosa pudica) ROOT EXTRACT AS WOUND HEALING AGENT

Background Knowledge Main Problem General Objective Significance of the Study Research Hypothesis Specific Objectives Usually, people’s common of idea of Makahiya (Mimosa pudica) is that its leaves fold up when touched. This diffusely spreading, half-woody herb, with branched stems up to 1 meter long, and sparingly prickly with numerous deflexed, bristly hairs is not only limited to that. It has been used in various fields especially in medicine.
Makahiya’s roots contain an alkaloid called mimosine. Mimosine is a non-protein amino acid found in leaves, pods and seeds of tropical legumes of the genus Leucaena. It is known to enhance cell proliferation and is highly toxic. How can we create effective
low-cost alternative wound healing agents? Feasibility of
Makahiya (Mimosa
pudica) Root
Extract as Wound
Healing Agent Getting sick is costly. We do not know how a simple wound can trigger more deadly diseases. The goal of this project is to create a cheaper but effective alternative wound healing agent. The methanolic extract from Mimosa pudica is an effective wound healing agent. It is a catalyst in Cicatrisation and is toxic enough to prevent further infection. Wounds occur when the skin is broken or damaged because of injury. The skin can be damaged in a variety of ways depending upon the mechanism of injury.
Superficial (on the surface) wounds and abrasions leave the deeper skin layers intact. These types of wounds are usually caused by friction rubbing against an abrasive surface. Deep abrasions, cuts, or lacerations, on the other hand, may go through all the layers of the skin and into underlying tissue like muscle or bone.
Wound healing or Cicatrisation is an intricate process in which the skin (or another organ-tissue) repairs itself after injury. This project specifically aims to: × determine whether the methanolic
extract from Mimosa pudica would make
for an effective wound healing agent
× determine whether it promotes faster
cell proliferation compared to the normal
healing process
× determine whether the mimosine isolated
from Mimosa pudica's roots is toxic
enough to keep germs and bacteria from
entering the incision during the
angiogenesis process Bibliography http://region3.dost.gov.ph/index.php?option=com_content&view=article&id=361:mimosa-pudica-root-extract-as-an-alternative-wound-healing-agent-&catid=22:medicine-and-health&Itemid=45
http://www.ncbi.nlm.nih.gov/pubmed/19397984
http://www.kew.org/plants-fungi/Mimosa-pudica.htm
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126448/
http://www.stuartxchange.com/Makahiya.html
http://www.emedicinehealth.com/wound_care/article_em.htm

The Philippines is a third-world country. Not all can afford to seek proper medical attention.
Wounds may get worse if not treated. Outcome also depends upon the risk factors present. Wounds that are contaminated and very dirty are more likely to become infected, and heal poorly than those that are not. If not attended to at an early stage, the more complicated the patient and the more complicated the wound, the prognosis for a perfect outcome decreases. The goal for all wounds is to have healing that allows the return of the injured part to its normal function.
This experiment tends to help those who have not the finances to avail expensive commercial ointment.
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