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Kannan Lab Research Overview
Transcript of Kannan Lab Research Overview
"Nothing in biology makes sense
except in the light of evolution."
Our model system:
The protein kinase family (kinome)
Over 500 kinases in the human genome
Over 250,000 from diverse organisms
More than 40% of the cellular
processes are controlled by protein
Cancer, Alzheimers, diabetes
Major targets for drug development
Sequencing the cancer kinomes
-Theodosius Dobzhansky (1900-1975)
Structural and functional diversity of the microbial kinome (2007)
Protein kinases in pathogens (apicomplexans) have evolved differently from those in their hosts.
If a conserved feature appears in the parasite but not its host, we may be able to selectively target the pathogen for drug development
(Former Grad. Student)
Currently post-doc at UCSF
Biomedical relevance and impact
Discovery of the
The Microbial Kinome
June 5, 2013
How did complexity in signaling systems evolve?
Can you use the evolutionary information encoded in genome sequences to decode signaling mechanisms?
What we do..
1. Quantify the similarities
and differences between
parasite and host kinases using statistical methods
2. Correlate sequence variation with functional/mechanistic variation
What we do...
1. Mine cancer genomes to predict driver mutations
2. Test the functional impact of mutations using cell based assays
3. Make our findings available through