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Microencapsulation for you

Scaling up solutions to competitively microencapsulate. Aimed to pharma, biotech, cosmetics, high value added ingredient
by

Ingeniatrics Tecnologias

on 20 August 2014

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Transcript of Microencapsulation for you

Easy Development of New Formulations
Innovation in existing Portfolio
Linear & Cost-Efficient Scalability
Simplicity
Proprietary Patented
Technology
Flow Focusing®
Flow Blurring®
Manufacturing know-how
Multiplexed Nebulization
Process
MODULARITY:
Same point in all nozzles!
Cellena, OneNeb, Spray Dryer…

Serial Manufacturing

Repeatability

Accuracy and precision

Flexible nozzles manufacturing
Microfluidics Expertise
- Research, Development, Engineering, Testing, Process
Qualification, & Certified
Manufacturing.
Manufacturing know-how
- Ultra fine aerosols, particles, emulsions, capsules, foams, jets, bubbles - for Pharmaceutical (ISO Class 7), Food (ISO Class 8), Chemistry
Proprietary
Technology. Protected by
70+ international patents
Professional multidisciplinary highly specialized
team
Large expertise in microencapsulation - Processes validation large showcase
Ingeniatrics’
capacities
High value
applications & industries
High value industries
(cc) photo by medhead on Flickr
High value applications
Protection
Dose control
Novel administrations
Combination of incompatibles
Design of delivery profiles
Stabilization
Biotech
Pharmaceuticals
Chemicals
Cosmetics
Nutrition, Functional Foods
Smart Textiles
Medicine
Diagnosis
EXPERTISE: Saving TIME-to-market!
Expertise:
Your Size,
Your Application
Melted substances: waxes, gums, …
Your Substance, Your Materials
Many validated processes book
Suitable for different liquids and compositions
Polymeric solutions: organic, aqueous, with additives, drugs, dyes …
Emulsions: compounds with different natures: hydrophilic/hydrophobic, polar/non-polar...
Suspensions: dispersions,nanoparticles,
living cells, microorganisms, …
5 microns - /polystyrene
15 microns cinnamon flavour /wax
150 microns Cells /alginate
Products
Flow Focusing® Bioencapsulation portable platform to encapsulate high molecular weight compounds, microorganisms and cells. Marketed by Biomedal
NE-4
High Throughput
Flow Blurring® Nebulizers, increases micrometric dispersion level, ability to work with conflicting dispersions, high operational robustness
low energy consumption, simplicity,
tested with nanoclays, lixiviates,…
Multiplexed Lab Spray Dryer
Spray Drying device, specially adapted to Flow Focusing® and Flow Blurring® own technology scaled up to 55 nebulizers running simultaneously for:
Functional Nutrition, Chemicals, Cosmetics, Personal Care, Textiles Care, Drug Delivery…
Flow Blurring® Nebulizers for
ICP-OES and ICP-MS spectrometry.
Marketed by Agilent Technologies
2001
2005
(cc) image by jantik on Flickr
Foundation of
Ingeniatrics
International
business
starts
2002
First service for a Big Pharma GSK
OneNeb®
and Frialia®
Launch
2010
Joint Venture
ZyxogenTM
World-wide Distribution
Agreement
Agilent
Cellena®
Launch
2011
Operational Plants:
Chemistry,
Food, Pharma
CUSTOMER-LED
: Market-driven activity, on-demand projects
Core-Shell
Core-Double
Shell
Expertise: Size, Application,
Substance, Materials

Customers’
benefits

Intellectual Property
Protection
Cost effective, Scale-able
, practical, reliable atomization
Modular
nozzles,
Flexible
production
system
Partner providing
World-class Expertise
and know-how to deliver user-friendly products and real solutions on time

Tangible products
on market
Save time, material and energy
Adaptive business model
Nebs and
Nozzle Head
Concentric Nebulizer
Flow Focusing Nebulization
Simple Nebulizer
Already Available
Neb Models
Flexible manufacturing system. We just…change the nozzle to
produce different models of Nebulizers
FLOW SPRAY DRYER
Polymers and Products
FLOW SPRAY DRYER
Most Significant Results
Microparticles by F. Blurring®
Nanoclays suspension (15 %), 0.5 -7 µm
Shellac, 0.5-7 µm
Maltodextrin, 0.3-4 µm
Own
Flow Focusing® Spray-Dryer
Cleanroom for
Pharma
Different Pilot-plants for

Nutrition
Chemicals
SCALE-ABLE
:
Costs going down at higher rate than productivity up!
Homogeneous
in a Matrix
AENOR certificates Ingeniatrics' Quality
Control and Environment management
according to ISO 9001 and 14001.
Pharmaceutical (ISO Class 7)

Food (ISO Class 8)
– Certified ISO 9001:2008, ISO 14001:2004

Chemistry
– Certified ISO 9001:2008, ISO 14001:2004
Microparticles by
F. Focusing®

Shellac, 5.4 µm
Maltodextrin, 8 µm
HPMCP, 10 µm
Shellac, 18 µm
Maltodextrin, 22 µm
Microcapsules by
Concentric F. Focusing®

HPMCP/ Coriander oil,
37 µm

Eudragit/ Coriander oil,
18 µm

Shellac + Maltodextrin/oily emulsion , 34 µm 38 µm
Ingeniatrics’ Capabilities
Lactobacillus,
31 µm
The more viscous, the more efficient -Up to 140 000 cP
FF - From
0,9
Microns to
7000
microns
Microparticles
by Flow Focusing®

ISO 9001
ISO 14001
2012
Frost & Sullivan 2011 Award
Alfonso Gañan Fellow APS- Physics
Full transcript