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Getting a grip on cells and tissues

레터릭 쇼 rhetoricShow@naver.com

on 23 August 2013

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Transcript of Getting a grip on cells and tissues

Getting a grip on CELLS and

learning objectives
INCREASED ENZYME SYNTHESIS: adaptation in order to inactivate or detoxify materials more efficiently
DYSPLASIA: Cells develop or mature abnormally. may proceed to neoplasia
METAPLASIA: change from one type of cell to a more resistant type
ATROPHY: reduction in size in response to unfavorable conditions
HYPERTROPHY: increase in cell size for more efficient function
HYPERPLASIA: increase in number of cells to increase functional capabilities
adaptations of
cells to changing conditions
List 5 processes by which cells
adapt to changing conditions
Explain 3 ways in which an aging cell becomes increasingly vulnerable to injury.
Describe the HLA system, and explain its application to organ transplantation and its relationship to disease susceptibility
Describe the applications and limitations of gene therapy
Describe the applications and limitations of gene therapy
Five processes of cellular adaptation to changing conditions
cell injury
cell swelling
fatty change
cell death and necrosis
cell death follows irreparable injury
structural changes that follow called necrosis
APOPTOSIS: programmed cell death
Aging and the Cell
less resistant to injury
cell's enzyme systems less active
lymphocytes less efficient
Major histocompatibility complex (MHC)

What is the difference between atrophy and hypertrophy?
Between metaplasia and dysplasia?
Between cell death and necrosis?
difference between cell death and necrosis?
What morphologic abnormalities are manifested by an injured cell?
Why do they develop?
What factors cause a cell to age?
What is it?
What is its function?
What is its relationship to disease development?
Found on chromosome 6
Determines antigens on cells
Sets us apart from others
First identified on peripheral blood leukocytes (HLA)
Different HLA types predispose to specific diseases such as type I diabetes, rheumatoid arthritis....autoimmune diseases
Mitochondrial DNA are numerous in ova.
Mutated and normal DNA present
Rare diseases transmitted from mother
regulatory proteins of immune response
proteins that activate clot dissolving mechanisms
Recombinant DNA : genes from two different sources recombined in single organism
Genetic engineering: Genes being manipulated
Gene splicing gene being cut open and another piece being spliced to it
Full transcript