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The Past, The Present, The Future of Nanotechnology and Hyperthermia Treatment
Transcript of The Past, The Present, The Future of Nanotechnology and Hyperthermia Treatment
most effective with polar (i.e. water)
rotation energy friction
basis for microwave cooking
John Yang The Past. The Present. The Future of Kanzius Radiofrequency Treatment Present Studies Future Studies Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma
Noninvasive Radiofrequency Field Destruction of Pancreatic Adenocarcinoma Xenografts Treated with Targeted Gold
Nanoparticles Pancreatic carcinoma cells are susceptible to noninvasive radio frequency ﬁelds after treatment with targeted gold nanoparticles
Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field Use of silver nanoparticles
Human clinical trials
Improving accuracy of targeting
Implications or problems? Introduction John S. Kanzius (1944-2009)
No degree from college
non-Hodgkin lymphoma (blood cancer)
includes any kind of lymphoma except Hodgkin's
Motivation from personal experience with chemotherapy 2005 Future 2012 The Past The Present Hyperthermia Form of treatment with elevated temperature
41-45 degrees Celsius
Least clinical side effects Problems difficulties in controlling agent transport
low heating temperature due to heat loss through space gap between the cells and hyperthermia agents
Damages healthy cells Kanzius Radiofrequency (RF) Hyperthermia Treatment Initial Questions
"What if I could make the cancer cells act like little radio receivers and pick up the signal?
"Would they get hot once they pick up the signal and create fever?" Kanzius took the idea to his oncologist at University of Texas MD. Anderson Cancer Center Dr. Steven A. Curley
idea that gold or metallic particles into malignant cells and heat with radio waves
Ideally, treatment does not have clinical side effects, while completely ablating malignant tissues. Steps leading up US Patent on System and Method For RF-Induced Hyperthermia Mechanism
RF absorption enhancer directly injected to targeted area
aqueous solutions containing suspended particles
electrically conductive material
i.e. colloidal gold, single-walled carbon nanotubes
antibodies or ligands attached
RF signal is transmitted ' Use of Media Funding Should the Kanzius Research Foundation turn to ________ for funding?
Other http://www.pueschner.com/basics/phys_basics_en.php http://upload.wikimedia.org/wikipedia/en/a/a3/JohnKanzius2005Photo.PNG http://www.nanohealthalliance.org/events-2/past-events/events-1/nanoparticles-as-intracellular-targets-to-produce-rf-induced-thermal-destruction-of-cancer-cells/ http://www.kanziuscancerresearch.org/about/our-mission http://www.wish.org/ http://www.standup2cancer.org/ Bibliography Alternative Cancer Treatment - Kanzius Cancer Research Foundation. (n.d.). Retrieved October 26, 012, from Alternative Cancer Treatment - Kanzius Cancer Research Foundation website: http://www.kanziuscancerresearch.org/ Self-heating nanoparticles as tumor-destroying hyperthermia agents. (2007, January 22). Retrieved October 28, 2012, from Nanotechnology Now website: http://www.nanotech-now.com/news.cgi?story_id=19851
Cadet, J. (2009, April 30). Cancer to increase by 45 percent over the next 20 years. Retrieved October 26, 2012, from Healthy Imaging website: http://www.healthimaging.com/topics/oncology-imaging/cancer-increase-45-percent-over-next-20-years
Cancer Future Predictions Article. (2009, May 4). Retrieved October 29, 2012, from LDN_4_Cancer website: http://health.groups.yahoo.com/group/LDN_4_cancer
Gannon. (2007). Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field. Cancer, 110(12), 2654-2665.
Glazer, E. S., Massey, K. L., Zhu, C., & Curley, S. A. (2010). Pancreatic carcinoma cells are susceptible to noninvasive radio frequency fields after treatment with targeted gold nanoparticles. Surgery, 148(2), 319-324
Glazer, E., Zhu, C., & Massey, K. (2010). Noninvasive Radiofrequency Field Destruction of Pancreatic Adenocarcinoma Xenografts Treated with Targeted Gold Nanoparticles. Clin Cancer Res, (16), 5712-5721.
Kanzius, J. (2005). U.S. Patent No. US20050251233. Washington, DC: U.S. Patent and Trademark Office.
Raoof, M., & Curley, S. A. (2011). Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma (2). International Journal of Hepatology, 2011, 1-6.
Using Gold, Silver & Carbon Nano-Particles to find a Cure for Cancer. (n.d.). Retrieved October 30, 2012, from Free Bullion Investment Guide website: http://www.free-bullion-investment-guide.com/cure-for-cancer.html