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Francis Crick


Candace Parr

on 14 November 2011

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Transcript of Francis Crick

Francis Crick* Background Born on june 8, 1916 in northampton, england
died july 28, 2004
attended mill hill school on scholarship
earned B.SC. Degree in physics from university of london
designed weapons for british admiralty
obtained phd with thesis work on x-ray diffraction of proteins X-ray Diffraction:
a technique used for studying the crystalline structure of molecules, permitting investigators to determine elements of three-dimensional structure Scientific Work Scientific Work began working under sir william lawrence bragg in 1941
applying the x-ray diffraction technique mainly to proteins
in 1951, he began work with j.d. watson studying genes
over two years, crick and watson studied and discussed the problem of dna
this relates to the notion that the chemist linus pauling proposed Linus Pauling proposed that proteins had a 3 dimensional
structure and were not simply linear strings of amino acids after this two year period, they used x-ray diffraction to create a dna molecule model that conformed to the findings of the london group and edward chargaff -- who believe that nucleotides that build dna existed in complimentary pairs These findings appeared in the journal Nature
which outlined the structure and function of
DNA along with papers of other colleagues and
scientists that supplied experimental evidence
that supported the Watson-Crick model Crick, along with Watson and maurice wilkins
were awarded the nobel prize in 1962 for
physiology or medicine "for their discoveries
concerning the molecular structure of nucleic
acids and its significance for information transfer
in living material" crick's continued genetic research led to what he
referred to as the "central dogma" of molecular biology... "Central Dogma of Molecular Biology":
once ‘information’ has passed into a protein, it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible crick also predicted the protein synthesis mechanism of transcription and translation, as well as coining the term "codon" Legacy of Work and the structure of DNA the discovery of the double helix structure of dna served
as a catalyst for new research, and is currently used
in all genetic studies today These important evidences brought rise to the DNA/RNA dictionary
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