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Transcript of Prions
Ongoing research suggests that the infection of Prion diseases in animals is through ingestion. It is also thought that Prion diseases are spread through the environment through the remains of animals via Urine, saliva or any other body fluids. TRANSMISSION Prions are infections by their on effects on the common versions of the protein. To sterilize a prion it would have to distort the protein to such a state that the molecule it self would be incapable of folding the normal proteins. Prions are normally fairly resistant to such things as proteases, heat, radiation, and formalin treatments, although these such things would be necessary to reduce the effect of the disease. STERILIZATION When Prions were discovered it was that that all of the pathogens has used nucleic acids to commence with their replication.This "protein-only hypothesis" supports the fact that a protein structure is able to replicate without the use of nucleic acids. PROTEIN ONLY Prions are immune to cause diseases by mixing with other cells in the central nervous system to create plaque called 'amyloid', which distorts the common tissue structure. Prion diseases to tend to stay effective for a long time and once the symptoms appear the disease progresses quickly, possibly leading to fatal or brain injuries. The symptoms may include dementia, ataxia and behavioural or personality distortion. VIRAL HYPOTHESIS Despite all the effort that has been put into this hypothesis, notable titers of the ineffectual behavior of prions have never actually been produced by refolding the common PrP molecules, which raises the doubt about the truth behind the 'protein only hypothesis'. The protein only hypothesis also fails to provide us a scientific explanation as to why the prion has the ability to target specific areas of our brain. All of these are the reasons that have given rise to the 'multi-component' hypothesis. MULTI-COMPONENT GENETIC FACTORS The gene for the normal protein has been identified as: the PRNP gene. In all cases that have ever been found of the Prion diseases there is always a sort of mutation in the PRNP gene. They are many different mutations and they are probably to fold into an abnormal prion. Mutations can occur through out the gene. as of this year, there are 8 known types of the Prion protein that have been discovered in fungi. A prion has been found in the fungus names Podospora Anseria. The prions in this fungus behave in the same manner as PrP, but are subsequently non toxic to their hosts. FUNGI Thankyou for watching:)