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Anabolic Steroids

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Patrick Calleo

on 14 April 2010

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Transcript of Anabolic Steroids

Anabolic Steroids Patrick Calleo What are Anabolic Steroids? Full name is anabolic androgenic steroids (AAS)

Mimic the effects of testosterone and dihydrotestosterone

History of Anabolic Steroids Late 19th century- Use of testicular extract
1931- Purification of androstenone from urine
1934- Androstenone synthesized
1935- Testosterone synthesized
1937- Clinical trials
1938- Strength and Health magazine
1958- Approval of methandrostenolone by FDA
1976- IOC added anabolic steroids to banned substance list
1988- Anti-Drug Abuse Act creates criminal penalties for distributing or possessing anabolic steroids
2004- MLB begins testing major league players
Pharmacology Routes of administration
Half-lives can range from a couple of minutes to 10 days
Quick acting
Can be detectable from a couple of days-18 months
Eliminated through urine, feces
Pharmacological Effects Increases synthesis of protein within cells

Buildup of cellular tissue (especially in muscles)

Blocking of cortisol on muscle tissue

Favors cell differentiation

Anabolic and virilizing properties

Naturally occurring testosterone
Synthetic steroid Methandrosenolone
What Are The Effects of Steroids?? Positive Effects of AAS Increased muscle fiber size
Enhances protein synthesis
Enhances work capacity
Reduces effects of fatigue
Cosmetic effects

Adverse Effects of AAS
Elevated blood pressure
Changes in cholesterol
Increase in cardiovascular disease
Liver damage
Hair loss/growth
Hypogonadal state
Increased aggression
Physical dependence
Abuse and Treatment Schedule III drug

Abuse- persists despite recognized unavoidable side effects


Treatment depends on addiction

Steroids in Sports
Steroids in track/cycling

Steroids in football

Steroids in baseball

Discussion of steroids in sports

Steroids in Track/Cycling Marion Jones admits steroid use in 2007

Some studies suggest the end of record setting by 2060

Floyd Landis

Hard to use AAS for endurance events
Steroids in Football Lyle Alzado- “I started taking anabolic steroids in 1969 and never stopped. It was addicting, mentally addicting. Now I'm sick, and I'm scared. Ninety percent of the athletes I know are on the stuff. We're not born to be 300 lbs or jump 30ft. But all the time I was taking steroids, I knew they were making me play better. I became very violent on the field and off it. I did things only crazy people do. Once a guy sideswiped my car and I beat the hell out of him. Now look at me. My hair's gone, I wobble when I walk and have to hold on to someone for support, and I have trouble remembering things. My last wish? That no one else ever dies this way”
Steroids in Football One of the most strict testing policies among professional sports

111 players have tested positive since 1987

Masking in the NFL vs. NCAA

Steroids in Baseball 1990- Anabolic Steroids Control Act
1998- Home run race- Mark McGwire and androstenedione
2001- MLB decides to test minor league baseball players
2003- Survey testing 5-7% fail testing
2004- Begin testing MLB players
2005- Juiced is released
2005- 1-2% fail official test, congressional hearings
2007- Mitchell report is released
2008- MLBPA accept new drug agreement
2009- Manny Ramirez suspended 50 games
Actors and hip-hop artists use it to get a bulkier appearance

Everyday adults trying to look younger

Use in cancer and AIDS patients

Use Outside of Sports Should Steroids be Legalized? Make stronger athletes

Make healthier people

More heart problems

More serious injuries

Questions? Who Uses Steroids? Athletes


Average Joes

Cancer and AIDS patients

The elderly
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