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High altitude physiology

bohr and haldane effect
by

Sergi Fluvià Sabio

on 4 June 2013

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Transcript of High altitude physiology

High altitude physiology High altitude conditions Blood gas
transport Bohr-haldane effect Bohr and Haldane effect Pressure and Oxigen AMB: Ambient
INSP: Inspired
ALV: Alveolus
ART: Arterial CO2/H+ are affecting the affinity of Hb for 02 O2 is affecting the affinity of Hb for CO2/H+ Bohr effect Haldane effect Bohr effect Oxygen–haemoglobin dissociation curve Do you remember?... Lungs Thigh } O2 delivered } { Bohr effect Haldane effect Carbon Dioxide Dissociation Curve Describes the fact that oxygen and carbon dioxide destabilize each other’s binding to hemoglobin. pH

Temp pH

Temp CO2 CO2 DPG DPG O2 O2 Thigh Lungs } } } Haldane effect CO2 delivered Let's recap... Blood gas transport
Bohr-Haldane effect
High altitude conditions Hypoxia decreased dissolved oxygen in the blood Stimulation of peripheral chemoreceptors Respiratory Alkalosis Shift the hemoglobin dissociation curve to the left 2,3-DPG level will increase Return to normal pH Breath more Hb can pick up O2 easier Shift the Hb curve to the right Making O2 delivery easier to tissues Why athletes go to the mountain before a competition? Right shifted Hb curve Easier O2 delivery to their muscles during competition We are at high altitude! High altitude conditions Sergi Fluvià Sabio
UPC-ESAB
Animal Physiology Bibliography Sally Osborne, Ph.D.Blood gas transport. Department of Cellular & Physiological Sciences
http://www.sallyosborne.com/Med%20Lecture-%20Transport%20Of%20Blood%20Gases.pdf Andrew J.Young, PhD.Human Adaptation to high terrestral altitude, Chapter 21.
https://ke.army.mil/bordeninstitute/published_volumes/harshEnv2/HE2ch21.pdf N.P Mason.The physiology og high altitude: an introduction to the cardio-respiratory changes ocurring on ascent to altitude.
http://www.ericjlee.com/Mountains/The%20Physiology%20of%20High%20Altitude.pdf Bohr Effect vs. Haldane Effect. khanacademymedicine
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